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Review
. 2021 Aug 27;13(8):879-886.
doi: 10.4254/wjh.v13.i8.879.

Pathogenesis of autoimmune hepatitis

Jun-Hua Fan  1 , Geng-Feng Liu  1 , Xiao-Dan Lv  2 , Rui-Zhi Zeng  1 , Ling-Ling Zhan  2 , Xiao-Ping Lv  3
Affiliations
Review

Pathogenesis of autoimmune hepatitis

Jun-Hua Fan et al. World J Hepatol. .

Abstract

Autoimmune hepatitis (AIH) is a chronic progressive liver disease whose etiology and pathogenesis are not yet clear. It is currently believed that the occurrence of AIH is closely related to genetic susceptibility and immune abnormalities, and other factors such as environment, viral infection and drugs that may cause immune dysfunction. This article reviews the pathogenesis of AIH and describes the latest research results in the past 5 years.

Keywords: Autoimmune hepatitis; Drug-induced liver injury; Genetic susceptibility; Immunomodulation; Intestinal microbes; environmental factors.

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Conflict of interest statement

Conflict-of-interest statement: The authors do not have any commercial or other associations that might pose a conflict of interest.

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