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Review
. 2021 Aug 8;19(3):370-375.
doi: 10.1080/2090598X.2021.1959260. eCollection 2021.

A systematic review on the latest developments in testosterone therapy: Innovations, advances, and paradigm shifts

Raed M Al-Zoubi  1   2 , Aksam A Yassin  1   3   4 , Mustafa Alwani  1   5 , Ahmad Al-Qudimat  1 , Omar M Aboumarzouk  1 , Ahmad Zarour  1 , Abdulla Al Ansari  1
Affiliations
Review

A systematic review on the latest developments in testosterone therapy: Innovations, advances, and paradigm shifts

Raed M Al-Zoubi et al. Arab J Urol. .

Abstract

Objectives: To review the latest innovations and advances in testosterone treatments including their advantages and disadvantages and to address important issues in testosterone therapy (TTh).

Methods: This review was conducted according to the Preferred Reporting Items for Systemic Reviews and Meta-analyses guidelines. The PubMed, MEDLINE, Scopus and Cochrane databases were searched using specifically related key words. The identified studies were screened for inclusion criteria that included studies discussing one of the four objectives of the systematic review: 1) cut-off references, 2) prevention/remission of type II diabetes mellitus (T2DM), 3) duration of treatment, and 4) prostate, lower urinary tract symptoms, prostate health, or cancer. The search was limited to the past 15 years. Any studies were not written in English were excluded.

Results: The initial literature search retrieved 393 studies. After screening four studies were removed due to duplication, 360 studies were further excluded after reviewing the title, abstract or the whole manuscript due to different exclusion criteria or being not focussed on the objective. Finally, 29 studies were included in the review. One study discussed the cut-off value, four studies discussed the effect of testosterone replacement therapy (TRT) on the control of T2DM, four studies on duration of TRT, and 20 studies discussed the effects of TRT on the prostate.

Conclusions: Numerous studies have demonstrated the benefits of TTh in overtly hypogonadal men. There are several possible administration routes for testosterone treatment. Each approach has advantages and disadvantages, and the choice of the method of TRT will often be determined by patient preference or co-medication (no intramuscular injections in patients under coumarin or similar anticoagulants). Although new developments are promising, it seems that among the available treatments, only transdermal gel delivery and long-acting injectable testosterone undecanoate provide pharmacokinetic behaviour that gives a steady state level within a physiological range.

Keywords: Hypogonadism; ageing male; diabetes; obesity; prostate health; sexual health; testosterone therapy.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram
See this image and copyright information in PMC

References

    1. Saad F, Gooren LJ, Haider A, et al. An exploratory study of the effects of 12-month administration of the novel long-acting testosterone undecanoate on measures of sexual function and the metabolic syndrome. Arch Androl. 2007Nov-Dec;53(6):353–357. - PubMed
    1. Yassin AA, Haffejee M.. Testosterone depot injection in male hypogonadism: a critical appraisal. Clin Interventions Aging. 2007;2(4):577–590. - PMC - PubMed
    1. Swerdloff RS, Dudley RE. A new oral testosterone undecanoate therapy comes of age for the treatment of hypogonadal men. Ther Adv Urol. 2020;12:1–16. - PMC - PubMed
    1. Bhasin S, Pencina M, Jasuja GK, et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham heart study and applied to three geographically distinct cohorts. J Clin Endocrinol Metab. 2011Aug;96(8):2430–2439. Epub 2011 Jun 22. . - PMC - PubMed
    1. Yassin A, Haider A, Haider K, et al. TTh in men with hypogonadism prevents progression from prediabetes to type 2 diabetes: eight-year data from a registry study. Cardiovasc Metab Risk. Published. 1June2019. DOI:10.2337/dc18-2388. - DOI - PubMed

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