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Review
. 2021 Dec;159(5):804-825.
doi: 10.1111/jnc.15519. Epub 2021 Oct 9.

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

Md Jakaria  1 , Abdel Ali Belaidi  1 , Ashley I Bush  1 , Scott Ayton  1
Affiliations
Review

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

Md Jakaria et al. J Neurochem. 2021 Dec.

Abstract

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While β-amyloid plaque and neurofibrillary tangles define the pathology of the disease, the mechanism of neurodegeneration is uncertain. Ferroptosis is an iron-mediated programmed cell death mechanism characterised by phospholipid peroxidation that has been observed in clinical AD samples. This review will outline the growing molecular and clinical evidence implicating ferroptosis in the pathogenesis of AD, with implications for disease-modifying therapies.

Keywords: Alzheimer's disease; ferroptosis; iron; phospholipid peroxidation and neurodegeneration.

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References

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