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Observational Study
. 2022 Jan;33(1):107-108.
doi: 10.1016/j.annonc.2021.09.009. Epub 2021 Sep 20.

Effects of active cancer treatment on safety and immunogenicity of COVID-19 mRNA-BNT162b2 vaccine: preliminary results from the prospective observational Vax-On study

Affiliations
Observational Study

Effects of active cancer treatment on safety and immunogenicity of COVID-19 mRNA-BNT162b2 vaccine: preliminary results from the prospective observational Vax-On study

F Nelli et al. Ann Oncol. 2022 Jan.
No abstract available

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Conflict of interest statement

Disclorure The authors have declared no conflicts of interest.

Figures

Figure 1
Figure 1
Antibody and seroconversion responses after either dose of mRNA-BNT162b2 vaccine. (A) Comparison of distributions and medians of anti-SARS-CoV-2 spike protein IgG titers (logarithmic values). Bars represent median values with 95% confidence interval. (B) Comparison of seroconversion response rates at a cut-off of 50 AU/ml. Control cohort, patients with discontinuation of active treatment by at least 28 days; exposed cohort, patients on active treatment within previous 28 days; timepoint-1, assessment before second mRNA-BNT162b2 vaccine dose; timepoint-3, assessment at 8 weeks after second vaccine dose.

References

    1. Kong X., Qi Y., Huang J., et al. Epidemiological and clinical characteristics of cancer patients with COVID-19: a systematic review and meta-analysis of global data. Cancer Lett. 2021;508:30–46. - PMC - PubMed
    1. Polack F.P., Thomas S.J., Kitchin N., et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383:2603–2615. - PMC - PubMed
    1. Baden L.R., El Sahly H.M., Essink B., et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384:403–416. - PMC - PubMed
    1. Goshen-Lago T., Waldhorn I., Holland R., et al. Serologic status and toxic effects of the SARS-CoV-2 BNT162b2 vaccine in patients undergoing treatment for cancer. JAMA Oncol. 2021 doi: 10.1001/jamaoncol.2021.2675. - DOI - PMC - PubMed
    1. Palich R., Veyri M., Marot S., et al. Weak immunogenicity after a single dose of SARS-CoV-2 mRNA vaccine in treated cancer patients. Ann Oncol. 2021;32:1051–1053. - PMC - PubMed