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Editorial
. 2021 Sep 23;22(1):276.
doi: 10.1186/s13059-021-02501-0.

Genome and metabolome: chance and necessity

Emanuel Gonçalves  1   2 , Christian Frezza  3
Affiliations
Editorial

Genome and metabolome: chance and necessity

Emanuel Gonçalves et al. Genome Biol. .
No abstract available

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Schematic of the role of environmental selective pressures on genetically heterogeneous cell population leading to clonal selection and expansion of cells harbouring canonical cancer “drive” mutations. In the bottom, promising experimental and computational techniques are listed that together can be used to molecularly characterize the cellular changes throughout carcinogenesis, including modelling metabolism at single-cell resolution to discern the metabolic environmental pressures that drive clonal selection. Driver mutations, depicted by a red nucleus, represent cells harbouring genetic alterations that predispose to cancer phenotypes. Neutral mutations, shown by different coloured nuclei, showcase cells with genetic alterations that are not associated with cancer and are generally lost upon environmental selection
See this image and copyright information in PMC

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