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Review
. 2021 Oct;39(4):653-673.
doi: 10.1016/j.det.2021.05.016. Epub 2021 May 31.

COVID-19 Vaccines and the Skin: The Landscape of Cutaneous Vaccine Reactions Worldwide

Qisi Sun  1 , Ramie Fathy  2 , Devon E McMahon  3 , Esther E Freeman  4
Affiliations
Review

COVID-19 Vaccines and the Skin: The Landscape of Cutaneous Vaccine Reactions Worldwide

Qisi Sun et al. Dermatol Clin. 2021 Oct.

Abstract

In 2021, we entered a new phase of the COVID-19 pandemic. As mass vaccinations are underway and more vaccines are approved, it is important to recognize cutaneous adverse events. We review the dermatologic manifestations of COVID-19 vaccines as reported in clinical trial data and summarize additional observational reports of skin reactions to COVID-19 vaccines. Early-onset local injection reactions were the most common cutaneous side effects observed in clinical trials; delayed injection reactions were the most common cutaneous side effect reported outside of clinical trials. Understanding the landscape of cutaneous manifestations to COVID-19 vaccines is key to providing appropriate vaccine guidance.

Keywords: Adverse; COVID-19; Cutaneous; Moderna; Reactions; Side effects; Urticaria; Vaccines.

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Conflict of interest statement

Disclosure Dr. Freeman is the Principal Investigator of the AAD/ILDS COVID-19 Dermatology Registry. The authors have nothing to disclose.

References

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    1. McMahon D.E., Amerson E., Rosenbach M., et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. J Am Acad Dermatol. 2021;85(1):46–55. - PMC - PubMed
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