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. 2021 Sep 23;11(9):e049026.
doi: 10.1136/bmjopen-2021-049026.

Predictors of unrecognised comorbid depression in patients with schizophrenia at Amanuel mental specialized hospital, Ethiopia: a cross-sectional study

Mohammed Ayalew  1 , Yared Reta  2 , Semira Defar  3
Affiliations

Predictors of unrecognised comorbid depression in patients with schizophrenia at Amanuel mental specialized hospital, Ethiopia: a cross-sectional study

Mohammed Ayalew et al. BMJ Open. .

Abstract

Background: The occurrence of depression in patients with schizophrenia (PWS) increases the risk of relapse, frequency and duration of hospitalisation, and decreases social and occupational functioning.

Objective: This study aimed to assess prevalence of unrecognised comorbid depression and its determinants in PWS.

Method: A cross-sectional study was conducted from 1 to 30 March 2019 at Amanuel mental specialized hospital among 300 PWS. The 9-item Calgary Depression Scale for Schizophrenia was used to assess comorbid depression. Logistic regression was used to determine the association between outcome and explanatory variables. Statistical significance was declared at p value <0.05 with 95% CI.

Results: The prevalence of unrecognised comorbid depression was found to be 30.3%. Living alone (adjusted OR (AOR)=3.49, 95% CI=0.45 to 8.36), having poor (AOR=4.43, 95% CI=1.45 to 13.58) and moderate (AOR=4.45, 95% CI=1.30 to 15.22) social support, non-adherence to medication (AOR=3.82, 95% CI=1.70 to 8.55), presenting with current negative symptoms such as asocialia (AOR=4.33, 95% CI=1.98 to 9.45) and loss of personal motivation (AOR=3.46, 95% CI=1.53 to 7.84), and having suicidal behaviour (AOR=6.83, 95% CI=3.24 to 14.41) were the significant predictors of comorbid depression in PWS.

Conclusion: This study revealed considerably a high prevalence of unrecognised comorbid depression among PWS. Therefore, clinicians consider timely screening and treating of comorbid depression in PWS.

Keywords: adult psychiatry; delirium & cognitive disorders; eating disorders; epilepsy; substance misuse; suicide & self-harm.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Comorbid depression in PWS at AMSH Addis Ababa, Ethiopia, 2019. AMSH, Amanuel mental specialized hospital; PWS, patients with schizophrenia.
See this image and copyright information in PMC

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References

    1. World Health Organization . World Health organization. the global burden of disease: 2004 update. Geneva: World Health Organization, 2008.
    1. Ekman M, Granstrom O, Omerov S, et al. . The societal cost of schizophrenia in Sweden. J Ment Health Policy Econ 2013;16:13–25. - PubMed
    1. Whiteford HA, Degenhardt L, Rehm J, et al. . Global burden of disease attributable to mental and substance use disorders: findings from the global burden of disease study 2010. Lancet 2013;382:1575–86. 10.1016/S0140-6736(13)61611-6 - DOI - PubMed
    1. Buckley PF, Miller BJ, Lehrer DS, et al. . Psychiatric comorbidities and schizophrenia. Schizophr Bull 2009;35:383–402. 10.1093/schbul/sbn135 - DOI - PMC - PubMed
    1. Siris SG BC. Depression and schizophrenia. 2nd ed. Hirsch SR WD, editor. Oxford, UK: Blackwell Publishing Ltd, 2003.