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. 2022 Jan;42(1):116-120.
doi: 10.1038/s41372-021-01207-2. Epub 2021 Sep 23.

Reference intervals for end-tidal carbon monoxide of preterm neonates

Sasikarn Pakdeeto  1   2 , Thomas R Christensen  3 , Timothy M Bahr  4   5   6 , Erick Gerday  7 , Mark J Sheffield  7 , Kyle S Christensen  8 , Sarayut Supapannachart  1   2 , Pracha Nuntnarumit  1   2 , Saranya Sukwiset  1   2 , Robin K Ohls  9 , Robert D Christensen  9   10
Affiliations

Reference intervals for end-tidal carbon monoxide of preterm neonates

Sasikarn Pakdeeto et al. J Perinatol. 2022 Jan.

Abstract

Objectives: We constructed reference intervals for end-tidal carbon monoxide (ETCOc) levels of neonates 28 0/7 to 34 6/7 weeks gestation in order to assess hemolytic rate.

Study design: This is a prospective four-NICU study in Bangkok, Thailand, and Utah, USA.

Results: Of 226 attempted measurements, 92% were successful. Values from day 1 through 28 were charted and upper (>95th percentile) reference interval limits calculated. During the entire 28 days, the ETCOc upper reference intervals from babies in Bangkok were higher than those in Utah (p < 0.01). No differences were found due to sex, or earliest vs. latest gestation at birth (both p > 0.1). Similar to term neonates, preterm neonates in Bangkok and Utah had higher ETCOc values during the first 48 h after birth than thereafter (p < 0.01).

Conclusions: Using this methodology, and the reference interval chart, the hemolytic rate of preterm infants ≥28 weeks can be assessed.

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