Postbiotics - when simplification fails to clarify

José Eleazar Aguilar-Toalá¹, Stefania Arioli², Pradip Behare³, Clara Belzer⁴, Roberto Berni Canani⁵, Jean-Marc Chatel⁶, Enza D'Auria⁷, Mônica Queiroz de Freitas⁸, Eran Elinav^{9

10}, Erick Almeida Esmerino⁸, Hugo S García¹¹, Adriano Gomes da Cruz¹², Aarón F González-Córdova¹³, Simone Guglielmetti¹⁴, Jonas de Toledo Guimarães⁸, Adrián Hernández-Mendoza¹³, Philippe Langella⁶, Andrea M Liceaga¹⁵, Marciane Magnani¹⁶, Rebeca Martin⁶, Mohammad Tamrin Mohamad Lal¹⁷, Diego Mora², Mehran Moradi¹⁸, Lorenzo Morelli¹⁹, Fabio Mosca^{20

21}, Filomena Nazzaro²², Tatiana Colombo Pimentel²³, Chao Ran²⁴, Chaminda Senaka Ranadheera²⁵, Maria Rescigno^{26

27}, Azucena Salas²⁸, Anderson S Sant'Ana²⁹, Katia Sivieri³⁰, Harry Sokol^{6

31

32}, Valentina Taverniti³³, Belinda Vallejo-Cordoba¹³, Jaroslav Zelenka³⁴, Zhigang Zhou³⁵

Affiliations

¹ Laboratory of Transformation and Emerging Technologies in Foods, National Autonomous University of Mexico, FES-Cuautitlan, Mexico.
² Division of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy.
³ Dairy Microbiology Division, ICAR-National Dairy Research Institute Karnal, Karnal, Haryana, India.
⁴ Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands.
⁵ Department of Translational Medical Science, ImmunoNutritionLab at CEINGE Advanced Biotechnologies Research Center, European Laboratory for the Investigation of Food Induced Diseases, Task Force for Microbiome Studies - University of Naples "Federico II", Naples, Italy.
⁶ Université Paris-Saclay, INRAE, AgroParisTech, MICALIS UMR1319, Jouy-en-Josas, France.
⁷ Allergy Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
⁸ Faculty of Veterinary, Federal University Fluminense, Niterói, Brazil.
⁹ Immunology department, Weizmann Institute of Science, Rehovot, Israel.
¹⁰ Microbiome and Cancer Division, DKFZ, Heidelberg, Germany.
¹¹ Unidad de Investigación y Desarrollo de Alimentos, TecMN-Instituto Tecnológico de Veracruz, Veracruz, Mexico.
¹² Department of Food, Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil.
¹³ Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C., Hermosillo, Mexico.
¹⁴ Division of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy. simone.guglielmetti@unimi.it.
¹⁵ Department of Food Science, Protein Chemistry & Bioactive Peptides Lab, Purdue University, West Lafayette, IN, USA.
¹⁶ Laboratory of Microbial Processes in Foods, Department of Food Engineering, Federal University of Paraíba, João Pessoa, Brazil.
¹⁷ Borneo Marine Research Institute, Universiti Malaysia Sabah, Sabah, Malaysia.
¹⁸ Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
¹⁹ Department for Sustainable Food Processes, Università Cattolica del Sacro Cuore, Piacenza, Italy. lorenzo.morelli@unicatt.it.
²⁰ Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IRCCS), Milan, Italy.
²¹ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
²² Institute of Food Science - Italian National Research Council, Avellino, Italy.
²³ Federal Institute of Paraná, Campus Paranavaí, Paraná, Brazil.
²⁴ Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.
²⁵ School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
²⁶ IRCCS Humanitas Research Hospital, Milan, Italy. maria.rescigno@hunimed.eu.
²⁷ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. maria.rescigno@hunimed.eu.
²⁸ IDIBAPS, CIBEREHD, Barcelona, Spain.
²⁹ Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, Brazil.
³⁰ Department of Biological Sciences, Faculty of Pharmaceutical Sciences, State University of São Paulo (UNESP), Araraquara, Brazil.
³¹ Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Paris, France.
³² Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.
³³ Division of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy. valentina.taverniti@unimi.it.
³⁴ Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czechia.
³⁵ China-Norway Joint Lab on Fish Gastrointestinal Microbiota, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.

PMID: 34556825
DOI: 10.1038/s41575-021-00521-6

Free article

Comment

Postbiotics - when simplification fails to clarify

José Eleazar Aguilar-Toalá et al. Nat Rev Gastroenterol Hepatol. 2021 Nov.

Free article

. 2021 Nov;18(11):825-826.

doi: 10.1038/s41575-021-00521-6.

Authors

Affiliations

¹ Laboratory of Transformation and Emerging Technologies in Foods, National Autonomous University of Mexico, FES-Cuautitlan, Mexico.
² Division of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy.
³ Dairy Microbiology Division, ICAR-National Dairy Research Institute Karnal, Karnal, Haryana, India.
⁴ Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands.
⁵ Department of Translational Medical Science, ImmunoNutritionLab at CEINGE Advanced Biotechnologies Research Center, European Laboratory for the Investigation of Food Induced Diseases, Task Force for Microbiome Studies - University of Naples "Federico II", Naples, Italy.
⁶ Université Paris-Saclay, INRAE, AgroParisTech, MICALIS UMR1319, Jouy-en-Josas, France.
⁷ Allergy Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
⁸ Faculty of Veterinary, Federal University Fluminense, Niterói, Brazil.
⁹ Immunology department, Weizmann Institute of Science, Rehovot, Israel.
¹⁰ Microbiome and Cancer Division, DKFZ, Heidelberg, Germany.
¹¹ Unidad de Investigación y Desarrollo de Alimentos, TecMN-Instituto Tecnológico de Veracruz, Veracruz, Mexico.
¹² Department of Food, Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil.
¹³ Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C., Hermosillo, Mexico.
¹⁴ Division of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy. simone.guglielmetti@unimi.it.
¹⁵ Department of Food Science, Protein Chemistry & Bioactive Peptides Lab, Purdue University, West Lafayette, IN, USA.
¹⁶ Laboratory of Microbial Processes in Foods, Department of Food Engineering, Federal University of Paraíba, João Pessoa, Brazil.
¹⁷ Borneo Marine Research Institute, Universiti Malaysia Sabah, Sabah, Malaysia.
¹⁸ Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
¹⁹ Department for Sustainable Food Processes, Università Cattolica del Sacro Cuore, Piacenza, Italy. lorenzo.morelli@unicatt.it.
²⁰ Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IRCCS), Milan, Italy.
²¹ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
²² Institute of Food Science - Italian National Research Council, Avellino, Italy.
²³ Federal Institute of Paraná, Campus Paranavaí, Paraná, Brazil.
²⁴ Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.
²⁵ School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
²⁶ IRCCS Humanitas Research Hospital, Milan, Italy. maria.rescigno@hunimed.eu.
²⁷ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. maria.rescigno@hunimed.eu.
²⁸ IDIBAPS, CIBEREHD, Barcelona, Spain.
²⁹ Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, Brazil.
³⁰ Department of Biological Sciences, Faculty of Pharmaceutical Sciences, State University of São Paulo (UNESP), Araraquara, Brazil.
³¹ Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Paris, France.
³² Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.
³³ Division of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy. valentina.taverniti@unimi.it.
³⁴ Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czechia.
³⁵ China-Norway Joint Lab on Fish Gastrointestinal Microbiota, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.

PMID: 34556825
DOI: 10.1038/s41575-021-00521-6

No abstract available

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Comment in

Reply to: Postbiotics - when simplification fails to clarify.
Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EMM, Sanders ME, Shamir R, Swann JR, Szajewska H, Vinderola G. Salminen S, et al. Nat Rev Gastroenterol Hepatol. 2021 Nov;18(11):827-828. doi: 10.1038/s41575-021-00522-5. Nat Rev Gastroenterol Hepatol. 2021. PMID: 34556824 No abstract available.

Comment on

The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics.
Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EMM, Sanders ME, Shamir R, Swann JR, Szajewska H, Vinderola G. Salminen S, et al. Nat Rev Gastroenterol Hepatol. 2021 Sep;18(9):649-667. doi: 10.1038/s41575-021-00440-6. Epub 2021 May 4. Nat Rev Gastroenterol Hepatol. 2021. PMID: 33948025 Free PMC article. Review.

References

1. Salminen, S. et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat. Rev. Gastroenterol. Hepatol. 18, 649–667 (2021). - DOI
1. Tsilingiri, K. & Rescigno, M. Postbiotics: what else? Benef. Microbes 4, 101–107 (2013). - DOI
1. Aguilar-Toalá, J. E. et al. Postbiotics: an evolving term within the functional foods field. Trends Food Sci. Technol. 75, 105–114 (2018). - DOI
1. Patel, R. M. & Denning, P. W. Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: what is the current evidence? Clin. Perinatol. 40, 11–25 (2013). - DOI
1. Collado, M. C., Vinderola, G. & Salminen, S. Postbiotics: facts and open questions. A position paper on the need for a consensus definition. Benef. Microbes 10, 711–719 (2019). - DOI

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Postbiotics - when simplification fails to clarify

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Postbiotics - when simplification fails to clarify

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