Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep 7:12:752329.
doi: 10.3389/fendo.2021.752329. eCollection 2021.

The 1-Hour Plasma Glucose: Common Link Across the Glycemic Spectrum

Michael Bergman  1
Affiliations
Review

The 1-Hour Plasma Glucose: Common Link Across the Glycemic Spectrum

Michael Bergman. Front Endocrinol (Lausanne). .

Abstract

Evidence from populations at risk for type 1 diabetes, type 2 diabetes or gestational diabetes substantiates the 1-hour plasma glucose as a sensitive alternative marker for identifying high-risk individuals when ß-cell function is relatively more functional. An elevated 1-hour plasma glucose could therefore diagnose dysglycemia and risk for complications across the glycemic spectrum. Reducing the 2-hour oral glucose tolerance test to 1-hour would reduce the burden on patients, likely reduce costs, and enhance its accessibility in practice.

Keywords: gestational diabetes; oral glucose tolerance test (OGTT); prediabetes; type 1 diabetes; type 2 diabetes.

PubMed Disclaimer

Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Elevated 1-hour plasma glucose: “common soil” pathophysiological mechanisms. Adapted from Fiorentino et al. (6).
See this image and copyright information in PMC

References

    1. Tuomi T, Santoro N, Caprio S, Cai M, Weng J, Groop L. The Many Faces of Diabetes: A Disease With Increasing Heterogeneity. Lancet (2014) 383(9922):1084–94. 10.1016/S0140-6736(13)62219-9 - DOI - PubMed
    1. Redondo MJ, Hagopian WA, Oram R, Steck AK, Vehik K, Weedon M, et al. . The Clinical Consequences of Heterogeneity Within and Between Different Diabetes Types. Diabetologia (2020) 63(10):2040–8. 10.1007/s00125-020-05211-7 - DOI - PMC - PubMed
    1. Sladek R. The Many Faces of Diabetes: Addressing Heterogeneity of a Complex Disease. Lancet Diabetes Endocrinol (2018) 6(5):348–9. 10.1016/S2213-8587(18)30070-6 - DOI - PubMed
    1. Ahlqvist E, Storm P, Käräjämäki A, Martinell M, Dorkhan M, Carlsson A, et al. . Novel Subgroups of Adult-Onset Diabetes and Their Association With Outcomes: A Data-Driven Cluster Analysis of Six Variables. Lancet Diabetes Endocrinol (2018) 6(5):361–9. 10.1016/S2213-8587(18)30051-2 - DOI - PubMed
    1. Morimoto A, Tatsumi Y, Deura K, Mizuno S, Ohno Y, Miyamatsu N, et al. . Impact of Impaired Insulin Secretion and Insulin Resistance on the Incidence of Type 2 Diabetes Mellitus in a Japanese Population: The Saku Study. Diabetologia (2013) 56(8):1671–9. 10.1007/s00125-013-2932-y - DOI - PubMed