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. 1986 Jan;83(2):419-22.
doi: 10.1073/pnas.83.2.419.

Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine

S S Deeb, C Disteche, A G Motulsky, R V Lebo, Y W Kan

Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine

S S Deeb et al. Proc Natl Acad Sci U S A. 1986 Jan.

Abstract

A cDNA clone of the human apolipoprotein B-100 was used as a hybridization probe to detect homologous sequences in both flow-sorted and in situ metaphase chromosomes. The results indicate that the gene encoding this protein is on the distal end of the short arm of chromosome 2 (2p23-2p24). RNA isolated from monkey small intestine contained sequences (6.5 and 18 kilobases) homologous to the cDNA of apolipoprotein B-100. These results are consistent with the hypothesis that one gene codes for both the intestinal (B-48) and the hepatic (B-100) forms.

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