Closing the Rift: Discovery of a novel virus receptor

Nathen E Bopp¹, Diana Fernández², Patricia V Aguilar³

Affiliations

¹ Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
² Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
³ Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA. Electronic address: pvaguila@utmb.edu.

PMID: 34559984
DOI: 10.1016/j.cell.2021.09.004

Free article

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Closing the Rift: Discovery of a novel virus receptor

Nathen E Bopp et al. Cell. 2021.

Free article

. 2021 Sep 30;184(20):5084-5086.

doi: 10.1016/j.cell.2021.09.004. Epub 2021 Sep 23.

Authors

Nathen E Bopp¹, Diana Fernández², Patricia V Aguilar³

Affiliations

¹ Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
² Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
³ Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA. Electronic address: pvaguila@utmb.edu.

PMID: 34559984
DOI: 10.1016/j.cell.2021.09.004

Abstract

In this issue of Cell, Ganaie et al. reports the identification of LRP1 as a receptor of the highly pathogenic Rift Valley fever virus. By using genome-wide CRISPR-Cas9 screening and functional studies, Ganaie et al. identified LRP1 and several co-factors as essential elements for virus infection.

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Lrp1 is a host entry factor for Rift Valley fever virus.
Ganaie SS, Schwarz MM, McMillen CM, Price DA, Feng AX, Albe JR, Wang W, Miersch S, Orvedahl A, Cole AR, Sentmanat MF, Mishra N, Boyles DA, Koenig ZT, Kujawa MR, Demers MA, Hoehl RM, Moyle AB, Wagner ND, Stubbs SH, Cardarelli L, Teyra J, McElroy A, Gross ML, Whelan SPJ, Doench J, Cui X, Brett TJ, Sidhu SS, Virgin HW, Egawa T, Leung DW, Amarasinghe GK, Hartman AL. Ganaie SS, et al. Cell. 2021 Sep 30;184(20):5163-5178.e24. doi: 10.1016/j.cell.2021.09.001. Epub 2021 Sep 23. Cell. 2021. PMID: 34559985 Free PMC article.

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Closing the Rift: Discovery of a novel virus receptor

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Closing the Rift: Discovery of a novel virus receptor

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