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Review
. 2021 Dec 1;81(23):5783-5799.
doi: 10.1158/0008-5472.CAN-21-1191. Epub 2021 Sep 24.

Recent Advances in Pediatric Cancer Research

Troy A McEachron  1 , Lee J Helman  2   3
Affiliations
Review

Recent Advances in Pediatric Cancer Research

Troy A McEachron et al. Cancer Res. .

Abstract

Over the past few years, the field of pediatric cancer has experienced a shift in momentum, and this has led to new and exciting findings that have relevance beyond pediatric malignancies. Here we present the current status of key aspects of pediatric cancer research. We have focused on genetic and epigenetic drivers of disease, cellular origins of different pediatric cancers, disease models, the tumor microenvironment, and cellular immunotherapies.

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Conflict of interest statement

Conflict of Interest: The authors have no financial interests to declare as it pertains to this manuscript

Figures

Figure 1:
Figure 1:. Features of pediatric tumors.
(A) SV’s are more common than SNVs. (B) Somatic mutations in TP53 are frequently recurrent and mutations in epigenetic genes are also common. (C) The mutation spectra between adult and pediatric tumors share little overlap. SNV, single nucleotide variant; SV, structural variant; Epi; epigenetic associated genes.
Figure 2:
Figure 2:. Comparison of germline and somatic mutations in pediatric versus adult cancers.
Germline variants are more frequently observed in pediatric cancer patients than in adult cancer patients whereas adult tumors have an increased somatic mutation burden than pediatric tumors.
See this image and copyright information in PMC

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