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. 2022 Mar 1;49(3):e53-e55.
doi: 10.1097/OLQ.0000000000001564.

Association of Bacterial Vaginosis With Higher Vaginal Indole Levels

Jyoti Sharma  1 , Kanupriya Gupta, Jane R Schwebke, William M Geisler, Christina A Muzny
Affiliations

Association of Bacterial Vaginosis With Higher Vaginal Indole Levels

Jyoti Sharma et al. Sex Transm Dis. .

Abstract

We adapted a simple hydroxylamine-based indole assay to detect indole from stored vaginal swab specimens from women with and without bacterial vaginosis (BV). Women with BV had significantly higher vaginal indole levels compared with women without BV (6451.5 vs 5632.4 μM; P = 0.01), suggesting that indole-producing bacteria are a component of BV.

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Conflict of interest statement

Conflict of Interest: C.A.M. is a consultant for Lupin Pharmaceuticals, BioFire Diagnostics, Cepheid, and PhagoMed. She has also received research funding support from Lupin Pharmaceuticals, as well as speaker honoraria from Abbott Molecular, Cepheid, Roche Diagnostics, and Becton Dickinson. J.R.S. is consultant for Talis, Gedea, PhagoMed, and Hologic. W.M.G. has received speaker honoraria from Hologic, Inc. and Sanofi and research funding from Hologic, Inc. K.G. and J.S. declare no conflicts of interest.

References

    1. Peebles K, Velloza J, Balkus JE, et al. High global burden and costs of bacterial vaginosis: A systematic review and meta-analysis. Sex Transm Dis2019; 46:304–311.
    1. Onderdonk AB, Delaney ML, Fichorova RN. The human microbiome during bacterial vaginosis. Clin Microbiol Rev2016; 29:223–238.
    1. Hillier SL, Nugent RP, Eschenbach DA, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The vaginal infections and prematurity study group. N Engl J Med1995; 333:1737–1742.
    1. Svare JA, Schmidt H, Hansen BB, et al. Bacterial vaginosis in a cohort of Danish pregnant women: Prevalence and relationship with preterm delivery, low birthweight and perinatal infections. BJOG2006; 113:1419–1425.
    1. Peipert JF, Montagno AB, Cooper AS, et al. Bacterial vaginosis as a risk factor for upper genital tract infection. Am J Obstet Gynecol1997; 177:1184–1187.

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