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. 2021 Sep;38(5):1012-1019.
doi: 10.1111/pde.14771. Epub 2021 Sep 24.

Vulvar vitiligo and lichen sclerosus in children: A clinical challenge

Giulia Veronesi  1 , Annalucia Virdi  1 , Miriam Leuzzi  1 , Carlotta Gurioli  1 , Marco Adriano Chessa  1 , Alba Guglielmo  1 , Iria Neri  1
Affiliations

Vulvar vitiligo and lichen sclerosus in children: A clinical challenge

Giulia Veronesi et al. Pediatr Dermatol. 2021 Sep.

Abstract

Vulvar vitiligo (VV) and vulvar lichen sclerosus (VLS), both feature skin and mucosal hypo-/depigmentation. The aim of this study was to describe the clinical and dermoscopic features of VV and VLS in the pediatric population, providing diagnostic clues, and to define their association. We performed a systematic literature review of the clinical and dermoscopic features of pediatric VV and VLS. An observational study was conducted on children affected by VLS associated with VV, referred to the Dermatology Unit of the Sant'Orsola Polyclinic in Bologna, Italy. Medical history, age at diagnosis, ethnicity, clinical and dermoscopic features, and symptoms were recorded for all patients. 124 cases of VLS and 10 cases of VV were reviewed. Clinical manifestations included hypo-/depigmented patches in both conditions, while ecchymosis/purpura and fissures/erosion were observed in VLS. Symptoms including pruritus, pain, or burning were reported only by VLS patients. In our study five patients with VLS associated with VV were retrieved. Clinical features included well-demarcated depigmented patches in VV and translucent areas, erythema, ecchymoses/purpura, and labial fusion in VLS. Dermoscopy showed white structureless areas with a whipped cream-like appearance, linear or dotted vessels, white chrysalis-like structures, erosion and red-purpuric blotches in VLS and reduced pigment network or pigment absence, intralesional spots of residual pigmentation and telangiectasias in VV. Symptoms were present in all patients. Both VV and VLS show hypo-/depigmented patches. In the presence of associated symptoms, possible VLS should be investigated with clinical and dermoscopic examination to achieve a prompt diagnosis.

Keywords: child; children; dermoscopy; vulvar lichen sclerosus; vulvar vitiligo.

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References

REFERENCES

    1. Alaniz VI, Rosen M, Mohr B, Markman L, Quint EH. 4-year-old girl · genital discomfort and dysuria · clitoral hood swelling · Blood blister on the labia minora · Dx? J Fam Pract. 2019;68(5):E8-E10.
    1. Arlen AM, Wang M, Vash-Margita A. Lichen sclerosus in prepubertal girls: an uncommon but treatable cause of lower urinary tract symptoms. Urology. 2020;137:e1-e2.
    1. Fischer GO. Vulval disease in pre-pubertal girls. Australas J Dermatol. 2001;42(4):225-234; quiz, 235-256.
    1. Garden AS. Vulvovaginitis and other common childhood gynaecological conditions. Arch Dis Child Educ Pract Ed. 2011;96(2):73-78.
    1. Gibbon KL, Bewley AP, Salisbury JA. Labial fusion in children: a presenting feature of genital lichen sclerosus? Pediatr Dermatol. 1999;16(5):388-391.

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