Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986 Mar;31(3):289-96.
doi: 10.1007/BF01318121.

Protection of gastric mucosa in rats. Differences between vagotomy, atropine, and PGE2

D Foschi, F Ferrante, L Varin, P Del Soldato, V Rovati
Comparative Study

Protection of gastric mucosa in rats. Differences between vagotomy, atropine, and PGE2

D Foschi et al. Dig Dis Sci. 1986 Mar.

Abstract

We have studied the protective effects of truncal vagotomy, atropine, and PGE2 against gastric mucosal injury produced by necrotizing agents (0.2 N NaOH, 0.6 N HCl, absolute ethanol), acetylsalicylic acid (ASA) and HCl, or serotonin (5HT). Vagotomy, atropine, and PGE2 prevent the effects of different noxious agents. Vagotomy is protective only against 5HT and against ASA + 0.15 N or 0.35 N HCl, whereas atropine and PGE2 are also protective against the necrotizing agents. The effectiveness of vagotomy against ASA + 0.35 N HCl does not depend on the inhibition of acid secretion and supports the hypothesis that removal of the vagal drive counteracts the effect of H+ back-diffusion.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Eur J Pharmacol. 1980 Nov 7;68(1):49-53 - PubMed
    1. Scand J Gastroenterol Suppl. 1982;72:255-9 - PubMed
    1. Proc Soc Exp Biol Med. 1980 Apr;163(4):528-33 - PubMed
    1. Gastroenterology. 1981 Jan;80(1):4-9 - PubMed
    1. Jpn J Pharmacol. 1979 Aug;29(4):670-3 - PubMed

Publication types