Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep 25;43(1):40.
doi: 10.1186/s41021-021-00208-z.

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Xiaobo Dong #  1 , Jun Wang #  2 , Gesheng Wang  3 , Jiayue Wang  1 , Lei Wang  1 , Yong Du  1
Affiliations

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Xiaobo Dong et al. Genes Environ. .

Abstract

Background: Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility.

Methods: A systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger's regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.

Results: The meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07-1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06-1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15-1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model.

Conclusions: Our meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.

Keywords: MTHFR A1298C; Meta-analysis; Polymorphism; Stroke.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The flow sheet of identification of eligible studies
Fig. 2
Fig. 2
Forest plots of the MTHFR A1298C polymorphism under different genetic models. a is the model of CC + CA VS TT; b is the model of CC VS CA + AA; c is the model of C VS A
Fig. 3
Fig. 3
Sensitivity analysis examining the association between the MTHFR A1298C polymorphism and risk of stroke under these model (CC + CA VS AA, CC VS CA + AA, C VS A
Fig. 4
Fig. 4
Begg’s funnel plot for publication bias analysis. a is the model of CC + CA VS TT; b is the model of CC VS CA + AA; c is the model of C VS A
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Francis J, Raghunathan S, Khanna P. The role of genetics in stroke. Postgrad Med J. 2007;83(983):590–595. doi: 10.1136/pgmj.2007.060319. - DOI - PMC - PubMed
    1. Malik R, Dichgans M. Challenges and opportunities in stroke genetics. Cardiovasc Res. 2018;114(9):1226–1240. - PubMed
    1. Bogiatzi C, Hackam DG, McLeod AI, Spence JD. Secular trends in ischemic stroke subtypes and stroke risk factors. Stroke. 2014;45(11):3208–3213. doi: 10.1161/STROKEAHA.114.006536. - DOI - PubMed
    1. Guzik A, Bushnell C. Stroke Epidemiology and Risk Factor Management. Continuum (Minneapolis, Minn). 2017;23(1, Cerebrovascular Disease):15–39. - PubMed
    1. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci U S A. 1998;95(22):13217–13220. doi: 10.1073/pnas.95.22.13217. - DOI - PMC - PubMed

LinkOut - more resources