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Review
. 2021 Nov:232:108849.
doi: 10.1016/j.clim.2021.108849. Epub 2021 Sep 24.

A hitchhiker's guide through the COVID-19 galaxy

Susanna Felsenstein  1 , Andreas Otto Reiff  2
Affiliations
Review

A hitchhiker's guide through the COVID-19 galaxy

Susanna Felsenstein et al. Clin Immunol. 2021 Nov.

Abstract

Numerous reviews have summarized the epidemiology, pathophysiology and the various therapeutic aspects of Coronavirus disease 2019 (COVID-19), but a practical guide on "how to treat whom with what and when" based on an understanding of the immunological background of the disease stages remains missing. This review attempts to combine the current knowledge about the immunopathology of COVID-19 with published evidence of available and emerging treatment options. We recognize that the information about COVID-19 and its treatment is rapidly changing, but hope that this guide offers those on the frontline of this pandemic an understanding of the host response in COVID-19 patients and supports their ongoing efforts to select the best treatments tailored to their patient's clinical status.

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Figures

Fig. 1
Fig. 1
WHO Ordinal 9 Point Scale and therapeutic options recommended and under investigation during the different disease stages.
See this image and copyright information in PMC

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References

    1. Zhu N., Zhang D., Wang W., et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382(8):727–733. - PMC - PubMed
    1. World Health Organization WHO Coronavirus (COVID-19) Dashboard 2021. https://covid19.who.int Available from:
    1. European Centers for Disease Prevention and Control Data on SARS-CoV-2 Variants in the EU/EEA 2021. https://www.ecdc.europa.eu/en/publications-data/data-virus-variants-covi... updated 09. Sept 2021. Available from:
    1. Centers for Disease Prevention and Control COVID Data Tracker. 2021. https://covid.cdc.gov/covid-data-tracker/#variant-proportions Available from:
    1. Wan Y., Shang J., Graham R., et al. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J. Virol. 2020;94(7) - PMC - PubMed