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. 2021 Aug 30;9(9):204.
doi: 10.3390/toxics9090204.

Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases

Valérie Forest  1 , Jérémie Pourchez  1 , Carole Pélissier  2   3 , Sabyne Audignon Durand  4   5 , Jean-Michel Vergnon  6   7 , Luc Fontana  2   3
Affiliations

Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases

Valérie Forest et al. Toxics. .

Abstract

The biomonitoring of nanoparticles in patients' broncho-alveolar lavages (BAL) could allow getting insights into the role of inhaled biopersistent nanoparticles in the etiology/development of some respiratory diseases. Our objective was to investigate the relationship between the biomonitoring of nanoparticles in BAL, interstitial lung diseases and occupational exposure to these particles released unintentionally. We analyzed data from a cohort of 100 patients suffering from lung diseases (NanoPI clinical trial, ClinicalTrials.gov Identifier: NCT02549248) and observed that most of the patients showed a high probability of exposure to airborne unintentionally released nanoparticles (>50%), suggesting a potential role of inhaled nanoparticles in lung physiopathology. Depending on the respiratory disease, the amount of patients likely exposed to unintentionally released nanoparticles was variable (e.g., from 88% for idiopathic pulmonary fibrosis to 54% for sarcoidosis). These findings are consistent with the previously performed mineralogical analyses of BAL samples that suggested (i) a role of titanium nanoparticles in idiopathic pulmonary fibrosis and (ii) a contribution of silica submicron particles to sarcoidosis. Further investigations are necessary to draw firm conclusions but these first results strengthen the array of presumptions on the contribution of some inhaled particles (from nano to submicron size) to some idiopathic lung diseases.

Keywords: biomonitoring; lung diseases; mineralogical analysis of broncho-alveolar lavages; nanoparticles; occupational exposure.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
The mineralogical analysis of metal load extracted from pulmonary fluids could be used as an indicator of exposure to nanoparticles and could contribute to the assessment of potential causal links between the presence of inhaled biopersistent nanoparticles in the lungs and respiratory diseases.
Figure 2
Figure 2
(A) Si particles concentration in bronchial wash (BW) and broncho-alveolar lavages (BAL) of patients suffering either from sarcoidosis or another type of ILD. (B) Ti particles concentration in BW and BAL of patients suffering either from idiopathic pulmonary fibrosis or another type of ILD. Comparison between the fractions containing either the submicron particles and the nanoparticles and ions. The median (in bold), minimal and maximal values, as well as the first and third quartiles are indicated. The number of patients (n) from each group is reported (please note that some data are missing because for technical reasons some BW and BAL samples could not be analyzed).
Figure 3
Figure 3
Distribution of the patients depending on their probability of exposure to unintentionally released nanoparticles.
Figure 4
Figure 4
(A) Distribution of patients depending on the probability of exposure to unintentionally released nanoparticles and depending on the origin of their disease. (B) Distribution of patients depending on the probability of exposure to unintentionally released nanoparticles and depending on the nature of their disease.
See this image and copyright information in PMC

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