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. 1986 Feb;83(4):833-5.
doi: 10.1073/pnas.83.4.833.

Theoretical calculation of relative binding affinity in host-guest systems

T P Lybrand, J A McCammon, G Wipff

Theoretical calculation of relative binding affinity in host-guest systems

T P Lybrand et al. Proc Natl Acad Sci U S A. 1986 Feb.

Abstract

The relative free energy of binding the anions Cl- and Br- to the macrotricyclic receptor SC24 in water has been computed by a computer simulation technique. This result and an incidental result for the relative free energy of hydration of the anions are in excellent agreement with experimental data. The simulation approach to ligand-receptor interactions that is described here has significant potential as a predictive tool in chemistry, biochemistry, and pharmacology.

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References

    1. Annu Rev Immunol. 1983;1:87-117 - PubMed
    1. Science. 1985 Feb 22;227(4689):849-56 - PubMed

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