Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Spring;20(2):297-306.
doi: 10.22037/ijpr.2020.113698.14435.

Plasma Concentration of Taurine Changes following Acetaminophen Overdose in Male Patients during Hospitalization

Mohammadreza Sattari  1   2 , Ali Ostadi  1   3 , Shokoufeh Hassani  4   5 , Zeynab Mazloumi  6 , Hamid Noshad  7 , Kayvan Mirnia  8 , Armin Salek Maghsoudi  4   5
Affiliations

Plasma Concentration of Taurine Changes following Acetaminophen Overdose in Male Patients during Hospitalization

Mohammadreza Sattari et al. Iran J Pharm Res. 2021 Spring.

Abstract

Changes in plasma concentration of taurine during hospitalization of acetaminophen poisoned patients have not been studied. Hepatotoxicity is a common consequence of acetaminophen overdose that may lead to acute liver failure. Numerous biomarkers for drug-induced liver injury have been explored. All biomarkers are usually obtainable 48 h following acetaminophen overdose. We have already introduced taurine as a non-specific early biomarker of acetaminophen overdose. This study aimed to follow up changes in plasma concentration of taurine during the first three days of acetaminophen overdose. Sixty-four male patients suffering from acetaminophen overdose were selected for the study. Four blood samples were taken from the patients every 12 h. Sixty blood samples were also taken from sixty healthy humans. The plasma concentration of taurine in both groups was analyzed an already developed HPLC method. Analysis of regression showed a significant correlation between means of plasma concentrations of taurine and acetaminophen, aspartate aminotransferase, Alanine aminotransferase, glutathione peroxidase, and prothrombin time during hospitalization. The high plasma concentration of taurine, 6 h or more after acetaminophen overdose, could be a useful early indicator of liver damage.

Keywords: Acetaminophen; Biomarker; Hepatotoxicity; Paracetamol; Taurine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of plasma taurine levels in healthy controls (A) and acetaminophen-poisoned patients (B) (P < 0.0001).
Figure 2
Figure 2
Changes of plasma concentrations of acetaminophen and taurine, during 48 h of hospitalization (A) and correlation between plasma concentrations of taurine and acetaminophen in acetaminophen-poisoned patients (B).
Figure 3
Figure 3
Changes of plasma concentrations of taurine and AST, during 48 h of hospitalization (A) and correlation between plasma concentrations of taurine and AST in acetaminophen-poisoned patients (B).
Figure 4
Figure 4
Changes of plasma concentrations of taurine and ALT, during 48 h of hospitalization (A) and correlation between plasma concentrations of taurine and ALT in acetaminophen-poisoned patients (B).
Figure 5
Figure 5
Changes of plasma concentration of taurine and PT, during 48h of hospitalization (A) and correlation between plasma concentration of taurine and PT in acetaminophen-poisoned patients (B).
Figure 6
Figure 6
Changes of plasma concentrations of acetaminophen and GPx, during 48h of hospitalization (A) and correlation between plasma concentrations of taurine and GPx in acetaminophen-poisoned patients (B)
See this image and copyright information in PMC

References

    1. Ramachandran A, Jaeschke H. Acetaminophen toxicity: novel insights into mechanisms and future perspectives. Gene Expr. . 2018;18:19–30. - PMC - PubMed
    1. Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-induced hepatotoxicity: a comprehensive update. J. Clin. Transl. Hepatol. . 2016;4:131–42. - PMC - PubMed
    1. Lancaster EM, Hiatt JR, Zarrinpar A. Acetaminophen hepatotoxicity: an updated review. Arch. Toxicol. . 2015;89:193–9. - PubMed
    1. Blieden M, Paramore LC, Shah D, Ben-Joseph R. A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. Expert. Rev. Clin. Pharmacol. . 2014;7:341–8. - PubMed
    1. Ghandforoush-Sattari M, Mashayekhi S. Admissions to the Cardiff Poisons Unit involving paracetamol poisoning (1989–2002) Toxicol. Environ. Chem. . 2008;90:663–71.