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. 2021 Aug 21;13(8):e17347.
doi: 10.7759/cureus.17347. eCollection 2021 Aug.

Association Between Coronary Artery Disease and Plasma Omentin-1 Levels

Priya Bai  1 , Fnu Abdullah  2 , Maham Lodi  3 , Mayur Sarhadi  4 , Anum Dilip  3 , Sibghatullah Shahab  5 , Fnu Yasir  5 , Maha Jahangir  6
Affiliations

Association Between Coronary Artery Disease and Plasma Omentin-1 Levels

Priya Bai et al. Cureus. .

Abstract

Introduction: Omentin-1 is secreted from visceral adipose tissue that contributes to chronic inflammatory diseases' pathogenesis, including cardiovascular events. In this case-control study, we will determine the association between plasma omentin and coronary artery disease (CAD).

Methods: This is a case-control study, conducted from June 2020 to April 2021 in the cardiology unit of a tertiary care hospital in Pakistan. Patients diagnosed with CAD (n = 300) within the last six months were included in the study. Another 300 participants without CAD and with similar demographic profiles were included in the control group. A blood sample of 5 ml was drawn from participants of both groups and sent to the laboratory to test for plasma omentin level.

Results: Plasma omentin level was significantly lower in patients with CAD compared to the patients without CAD (61.21 ± 10.21 ng/dL vs. 95.22 ± 12.21 ug/L; p-value: <0.0001). In both genders, the plasma omentin-1 was lower in patients with CAD compared to patients without CAD (p-value: <0.0001).

Conclusion: The present study revealed a negative association between omentin-1 and CAD. We speculate that low levels of omentin-1 might play a role in the pathogenesis of atherosclerosis. Therefore, plasma omentin-1 can be a potential biomarker to predict the development and progression of CAD.

Keywords: cad; cardiovascular disease; coronary artery disease; intelectin-1; omentin-1.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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