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. 2021 Oct 22;84(10):2755-2761.
doi: 10.1021/acs.jnatprod.1c00812. Epub 2021 Sep 26.

Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana

Hugues Fouotsa  1   2   3 , Pierre Le Pogam  1 , Pierre Mkounga  2 , Alain Meli Lannang  4 , Guillaume Bernadat  1 , Jérôme Vanheuverzwijn  3 , Zhiyu Zhou  3 , Karine Leblanc  1 , Somia Rharrabti  1 , Augustin Ephrem Nkengfack  2 , Jean-François Gallard  5 , Véronique Fontaine  3 , Franck Meyer  3 , Erwan Poupon  1 , Mehdi A Beniddir  1
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Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana

Hugues Fouotsa et al. J Nat Prod. .

Abstract

Voatriafricanines A and B (1 and 2), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of Voacanga africana, guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds 1 and 2 possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound 1 exhibited potent antimycobacterial activity with no discernible cytotoxic activity.

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