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. 1986:14 Suppl 1:S67-9.
doi: 10.1007/BF01645203.

Pharmacokinetics of ofloxacin and theophylline alone and in combination

J B Fourtillan, J Granier, B Saint-Salvi, J Salmon, A Surjus, D Tremblay, M Vincent Du Laurier, S Beck

Pharmacokinetics of ofloxacin and theophylline alone and in combination

J B Fourtillan et al. Infection. 1986.

Abstract

The pharmacokinetic interactions of ofloxacin (2 X 200 mg) and theophylline (3 X 200 mg) were investigated in 12 healthy volunteers over a period of two weeks. In the first week, theophylline was given over five days to reach a steady state. In the second week, the combination of theophylline and ofloxacin was applied. Cmax, tmax, AUC0-8, the serum elimination constant and serum half-life of theophylline were not changed when theophylline was given alone or in combination with ofloxacin. The kinetic parameters of ofloxacin were in accordance with data from the literature.

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