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. 2021;84(2):607-608.
doi: 10.3233/JAD-215201.

The Use of Standardized Diesel Exhaust Particles in Alzheimer's Disease Research

Michelle L Block  1   2 , Urmila P Kodavanti  3
Affiliations

The Use of Standardized Diesel Exhaust Particles in Alzheimer's Disease Research

Michelle L Block et al. J Alzheimers Dis. 2021.

Abstract

The mechanisms underlying how urban air pollution exposure conveys Alzheimer's disease risk and affects plaque pathology is largely unknown. Because particulate matter, the particle component of urban air pollution, varies across location, pollution source, and time, a single model representative of all ambient particulate matter is unfeasible for research investigating the role of ar pollution in central nervous system diseases. More specifically, the investigation of several models of particulate matter with enrichment of source-specific components are essential to employ, in order to more fully understand what characteristics of particulate matter affects Alzheimer's disease, including standardized diesel exhaust particles.

Keywords: Air pollution; Alzheimer’s disease; diesel exhaust particles; particulate matter models.

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References

    1. Croze ML, Zimmer L (2018) Ozone Atmospheric Pollution and Alzheimer’s Disease: From Epidemiological Facts to Molecular Mechanisms. Journal of Alzheimer’s Disease 62, 503–522. - PubMed
    1. Kilian J, Kitazawa M (2018) The emerging risk of exposure to air pollution on cognitive decline and Alzheimer’s disease – Evidence from epidemiological and animal studies. Biomedical Journal 41, 141–162. - PMC - PubMed
    1. Iaccarino L, La Joie R, Lesman-Segev OH, Lee E, Hanna L, Allen IE, Hillner BE, Siegel BA, Whitmer RA, Carrillo MC, Gatsonis C, Rabinovici GD (2020) Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment. JAMA Neurology. - PMC - PubMed
    1. Farahani VJ, Pirhadi M, Sioutas C (2021) Are standardized diesel exhaust particles (DEP) representative of ambient particles in air pollution toxicological studies? Sci Total Environ 788, 147854. - PMC - PubMed
    1. Roque PJ, Dao K, Costa LG (2016) Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms. Neurotoxicology 56, 204–214. - PMC - PubMed

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