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. 1986 Apr;127(1):83-8.
doi: 10.1002/jcp.1041270111.

Transforming growth factor type beta regulation of actin mRNA

E B Leof, J A Proper, M J Getz, H L Moses

Transforming growth factor type beta regulation of actin mRNA

E B Leof et al. J Cell Physiol. 1986 Apr.

Abstract

Stimulation of quiescent cultures of AKR-2B cells with transforming growth factor type beta (TGF beta) resulted in a transitory increase in actin cytoplasmic poly(A) + RNA. Levels of actin mRNA peaked approximately 4-8 hours subsequent to TGF beta addition and approached basal levels by 24 hours. The accumulation of actin transcripts was dose dependent and insensitive to inhibitors of protein synthesis; 1-3 ng/ml TGF beta induced maximal actin gene expression. Actin isotype-specific probes demonstrated that both beta- and gamma-cytoplasmic actins are induced by TGF beta.

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