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. 1986 Apr;77(4):1405-8.
doi: 10.1172/JCI112450.

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro

L M Slater, P Sweet, M Stupecky, S Gupta

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro

L M Slater et al. J Clin Invest. 1986 Apr.

Abstract

The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.

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