Review

. 2021 Sep 18;9(9):1266.

doi: 10.3390/biomedicines9091266.

Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2

Priti Tagde^{1

2}, Sandeep Tagde², Pooja Tagde³, Tanima Bhattacharya^{4

5}, Shams Minhaz Monzur⁶, Md Habibur Rahman^{7

8}, Pavel Otrisal⁹, Tapan Behl¹⁰, Syed Shams Ul Hassan^{11

12}, Mohamed M Abdel-Daim^{13

14}, Lotfi Aleya¹⁵, Simona Bungau^{16

17}

Affiliations

¹ Bhabha Pharmacy Research Institute, Bhabha University, Bhopal 462026, India.
² PRISAL Foundation, Pharmaceutical Royal International Society, Bhopal 462042, India.
³ Practice of Medicine Department, Government Homeopathic Medical College, Bhopal 462003, India.
⁴ School of Chemistry and Chemical Engineering, Hubei University, Hubei 430062, China.
⁵ Techno India NJR Institute of Technology, Udaipur 313003, India.
⁶ Integro Global Ltd., Dhaka 1206, Bangladesh.
⁷ Department of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, Bangladesh.
⁸ Department of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh.
⁹ Faculty of Physical Culture, Palacký University Olomouc, 77111 Olomouc, Czech Republic.
¹⁰ Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
¹¹ Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
¹² Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
¹³ Department of Pharmaceutical Sciences, Batterjee Medical College, P.O. Box 6231, Jedah 21442, Saudi Arabia.
¹⁴ Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
¹⁵ Chrono-Environment CNRS 6249, Université de Franche-Comté, 25000 Besançon, France.
¹⁶ Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
¹⁷ Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.

PMID: 34572452
PMCID: PMC8468567
DOI: 10.3390/biomedicines9091266

Review

Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2

Priti Tagde et al. Biomedicines. 2021.

. 2021 Sep 18;9(9):1266.

doi: 10.3390/biomedicines9091266.

Authors

Affiliations

¹ Bhabha Pharmacy Research Institute, Bhabha University, Bhopal 462026, India.
² PRISAL Foundation, Pharmaceutical Royal International Society, Bhopal 462042, India.
³ Practice of Medicine Department, Government Homeopathic Medical College, Bhopal 462003, India.
⁴ School of Chemistry and Chemical Engineering, Hubei University, Hubei 430062, China.
⁵ Techno India NJR Institute of Technology, Udaipur 313003, India.
⁶ Integro Global Ltd., Dhaka 1206, Bangladesh.
⁷ Department of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, Bangladesh.
⁸ Department of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh.
⁹ Faculty of Physical Culture, Palacký University Olomouc, 77111 Olomouc, Czech Republic.
¹⁰ Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
¹¹ Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
¹² Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
¹³ Department of Pharmaceutical Sciences, Batterjee Medical College, P.O. Box 6231, Jedah 21442, Saudi Arabia.
¹⁴ Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
¹⁵ Chrono-Environment CNRS 6249, Université de Franche-Comté, 25000 Besançon, France.
¹⁶ Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
¹⁷ Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.

PMID: 34572452
PMCID: PMC8468567
DOI: 10.3390/biomedicines9091266

Abstract

The worldwide transmission of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a deadly or devastating disease is known to affect thousands of people every day, many of them dying all over the planet. The main reason for the massive effect of COVID-19 on society is its unpredictable spread, which does not allow for proper planning or management of this disease. Antibiotics, antivirals, and other prescription drugs, necessary and used in therapy, obviously have side effects (minor or significant) on the affected person, there are still not clear enough studies to elucidate their combined effect in this specific treatment, and existing protocols are sometimes unclear and uncertain. In contrast, it has been found that nutraceuticals, supplements, and various herbs can be effective in reducing the chances of SARS-CoV-2 infection, but also in alleviating COVID-19 symptoms. However, not enough specific details are yet available, and precise scientific studies to validate the approved benefits of natural food additives, probiotics, herbs, and nutraceuticals will need to be standardized according to current regulations. These alternative treatments may not have a direct effect on the virus or reduce the risk of infection with it, but these products certainly stimulate the human immune system so that the body is better prepared to fight the disease. This paper aims at a specialized literary foray precisely in the field of these "cures" that can provide real revelations in the therapy of coronavirus infection.

Keywords: COVID-19; SARS-CoV-2; herbs; nutraceuticals; probiotics; supplements; therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
PRISMA flow-chart summarizing the criteria of selection of the literature. MeSH = Medical Subject Heading.

**Figure 2**
Structure and spread mechanism of the human coronavirus (Created with BioRender.com).

**Figure 3**
Targeting SARS-CoV viral entry mechanism. RBD, Receptor-binding domain; ACE2, Angiotensin-converting enzyme 2. (Created with BioRender.com).

See this image and copyright information in PMC

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Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2

Affiliations

Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2

Authors

Affiliations

Abstract

Conflict of interest statement

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