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Review
. 2021 Sep 21;9(9):1282.
doi: 10.3390/biomedicines9091282.

In Vivo Experimental Endovascular Uses of Cyanoacrylate in Non-Modified Arteries: A Systematic Review

Kévin Guillen  1   2 , Pierre-Olivier Comby  2   3 , Olivier Chevallier  1   2 , Anne-Virginie Salsac  4 , Romaric Loffroy  1   2
Affiliations
Review

In Vivo Experimental Endovascular Uses of Cyanoacrylate in Non-Modified Arteries: A Systematic Review

Kévin Guillen et al. Biomedicines. .

Abstract

Cyanoacrylates were first used for medical purposes during World War II to close skin wounds. Over time, medical applications were developed, specifically in the vascular field. Uses now range from extravascular instillation in vascular grafting to intravascular injection for embolization. These applications were made possible by the conduct of numerous preclinical studies involving a variety of tests and outcome measures, including angiographic and histological criteria. Cyanoacrylates were first harshly criticized by vascular surgeons, chiefly due to their fast and irreversible polymerization. Over the past five years, however, cyanoacrylates have earned an established place in endovascular interventional radiology. Given the irreversible effects of cyanoacrylates, studies in animal models are ethically acceptable only if supported by reliable preliminary data. Many animal studies of cyanoacrylates involved the experimental creation of aneurysms or arteriovenous fistulas, whose treatment by endovascular embolization was then assessed. In clinical practice, however, injection into non-modified arteries may be desirable, for instance, to deprive a tumor of its vascular supply. To help investigators in this field select the animal models and procedures that are most appropriate for their objectives, we have reviewed all published in vivo animal studies that involved the injection of cyanoacrylates into non-modified arteries to discuss their main characteristics and endpoints.

Keywords: NBCA; animal studies; artery; artery model; cyanoacrylate; dog; endovascular; rabbit; rat; swine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart. WOS, Web of Science; AVM, arteriovenous malformation.
Figure 2
Figure 2
Percentage of studies identified during consecutive 8-year periods from 1972 to 2020.
Figure 3
Figure 3
Geographical distribution of the first authors of the included studies (graphic indicates the number of publications of each country).
Figure 4
Figure 4
Percentages of studies that used each embolization site; the denominator was the total number of studies with quantitative data (n = 36).
See this image and copyright information in PMC

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