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Review
. 2021 Sep 13;13(18):4590.
doi: 10.3390/cancers13184590.

Perioperative Systemic Chemotherapy for Colorectal Liver Metastasis: Recent Updates

Hee Yeon Lee  1 , In Sook Woo  1
Affiliations
Review

Perioperative Systemic Chemotherapy for Colorectal Liver Metastasis: Recent Updates

Hee Yeon Lee et al. Cancers (Basel). .

Abstract

The liver is the most common site of metastases for colorectal cancer. Complete resection in some patients with resectable liver metastases (LM) can lead to long-term survival and cure. Adjuvant systemic chemotherapy after complete resection of LM improves recurrence-free survival; however, the overall survival benefit is not clear. In selected patients, preoperative systemic treatment for metastatic colorectal cancer can convert unresectable to resectable cancer. This review will focus on patient selection, and integration of perioperative and postoperative systemic treatment to surgery in resectable and initially unresectable LM. Additionally, new drugs and biomarkers will be discussed.

Keywords: adjuvant chemotherapy; colorectal neoplasms; liver; metastasis; neoadjuvant therapy.

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Conflict of interest statement

The authors declare the absence of any conflict of interest related to the study or its submission for publication.

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