Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 31;12(9):1371.
doi: 10.3390/genes12091371.

Surgical Management of Hereditary Breast Cancer

Elizabeth R Berger  1 , Mehra Golshan  1
Affiliations
Review

Surgical Management of Hereditary Breast Cancer

Elizabeth R Berger et al. Genes (Basel). .

Abstract

The identification that breast cancer is hereditary was first described in the nineteenth century. With the identification of the BRCA1 and BRCA 2 breast/ovarian cancer susceptibility genes in the mid-1990s and the introduction of genetic testing, significant advancements have been made in tailoring surveillance, guiding decisions on medical or surgical risk reduction and cancer treatments for genetic variant carriers. This review discusses various medical and surgical management options for hereditary breast cancers.

Keywords: genetic variants; hereditary breast cancer; risk reducing surgery.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Broca P. Traite des Tumerurs. P. Asselin; Paris, France: 1866.
    1. Claus E.B., Schildkraut J., Iversen E.S., Jr., Berry D., Parmigiani G. Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history. J. Natl. Cancer Inst. 1998;90:1824–1829. doi: 10.1093/jnci/90.23.1824. - DOI - PubMed
    1. Familial breast cancer: Collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet. 2001;358:1389–1399. doi: 10.1016/S0140-6736(01)06524-2. - DOI - PubMed
    1. Miki Y., Swensen J., Shattuck-Eidens D., Futreal P.A., Harshman K., Tavtigian S., Liu Q., Cochran C., Bennett L.M., Ding W. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266:66–71. doi: 10.1126/science.7545954. - DOI - PubMed
    1. Wooster R., Bignell G., Lancaster J., Swift S., Seal S., Mangion J., Collins N., Gregory S., Gumbs C., Micklem G., et al. Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995;378:789–792. doi: 10.1038/378789a0. - DOI - PubMed

MeSH terms

Supplementary concepts