Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Mar 13;135(2):397-402.
doi: 10.1016/0006-291x(86)90008-2.

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

T Tamaoki, H Nomoto, I Takahashi, Y Kato, M Morimoto, F Tomita

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

T Tamaoki et al. Biochem Biophys Res Commun. .

Abstract

Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca++dependent protein kinase (protein kinase C) from rat brain, with an IC50 value of 2.7 nM. However, it had little effect on the binding of 3H-phorbol-12, 13-dibutyrate (PDBu) to protein kinase C. The inhibition of protein kinase C was not competitive with phospholipid. This compound also showed the strong cytotoxic effect on the growth of HeLa S3 cells, with an IC50 value of 4 X 10(-12)M under the condition of 72 hr-exposure.

PubMed Disclaimer

LinkOut - more resources