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Review
. 2021 Sep 14;22(18):9950.
doi: 10.3390/ijms22189950.

Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions

Gianluca Businello  1 , Valentina Angerilli  1 , Paola Parente  2 , Stefano Realdon  3 , Edoardo Savarino  4 , Fabio Farinati  4 , Federica Grillo  5   6 , Alessandro Vanoli  7 , Francesca Galuppini  1 , Silvia Paccagnella  1 , Gianmaria Pennelli  1 , Luca Mastracci  5   6 , Luca Saragoni  8 , Matteo Fassan  1   3
Affiliations
Review

Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions

Gianluca Businello et al. Int J Mol Sci. .

Abstract

Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process.

Keywords: biomarkers; gastric carcinogenesis; gastric carcinoma; pathology; pre-neoplastic lesions.

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Conflict of interest statement

The authors declare no conflict of interest regarding the present work.

Figures

Figure 1
Figure 1
Histopathological stages and related principal molecular alterations in intestinal-type gastric cancer oncogenesis. Hp: Helicobacter pylori; ChG: chronic gastritis; IM/GAC: intestinal metaplasia/chronic atrophic gastritis; LGD: low-grade dysplasia; HGD: high-grade dysplasia; IGAC: intestinal-type gastric adenocarcinoma. The histological pictures were taken from routine diagnostic cases and have not been previously used for any other publication.
See this image and copyright information in PMC

References

    1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Anderson W.F., Camargo M.C., Fraumeni J.F., Correa P., Rosenberg P.S., Rabkin C.S. Age-specific trends in incidence of noncardia gastric cancer in US adults. JAMA. 2010;303:1723–1728. doi: 10.1001/jama.2010.496. - DOI - PMC - PubMed
    1. Rubenstein J.H., Taylor J.B. Meta-analysis: The association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux. Aliment. Pharmacol. Ther. 2010;32:1222–1227. doi: 10.1111/j.1365-2036.2010.04471.x. - DOI - PMC - PubMed
    1. Gullo I., Grillo F., Mastracci L., Vanoli A., Carneiro F., Saragoni L., Limarzi F., Ferro J., Parente P., Fassan M. Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes. Pathologica. 2020;112:166–185. doi: 10.32074/1591-951X-166. - DOI - PMC - PubMed
    1. Choi Y.J., Kim N. Gastric cancer and family history. Korean J. Intern. Med. 2016;31:1042–1053. doi: 10.3904/kjim.2016.147. - DOI - PMC - PubMed