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Review
. 2021 Sep 17;14(18):5371.
doi: 10.3390/ma14185371.

Lipid-Based Drug Delivery Systems in Regenerative Medicine

Nina Filipczak  1 , Satya Siva Kishan Yalamarty  1 , Xiang Li  1   2 , Muhammad Muzamil Khan  3 , Farzana Parveen  1   3 , Vladimir Torchilin  1   4
Affiliations
Review

Lipid-Based Drug Delivery Systems in Regenerative Medicine

Nina Filipczak et al. Materials (Basel). .

Abstract

The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its natural healing potential. Regenerative medicine utilizes products of cell therapy, as well as biomedical or tissue engineering, and is a huge field for development. In regenerative medicine, stem cells and growth factor are mainly used; thus, innovative drug delivery technologies are being studied for improved delivery. Drug delivery systems offer the protection of therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. Similarly, the delivery systems in combination with stem cells offer improvement of cell survival, differentiation, and engraftment. The present review summarizes the significance of biomaterials in tissue engineering and the importance of colloidal drug delivery systems in providing cells with a local environment that enables them to proliferate and differentiate efficiently, resulting in successful tissue regeneration.

Keywords: colloids; drug delivery systems; gene delivery; lipid nanoparticles; micelles; protein delivery; regenerative medicine.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Regenerative medicine: different types of therapy (based on [3]).
Figure 2
Figure 2
Types of the delivery vehicles used in regeneration therapies for soluble factors. Macroscopic carriers: hydrogels (A) and electrospun fibers (B). Microscopic carriers: liposomes and micelles (C.1), dendrimers (C.2), or particulate hydrogel systems (C.3). Viral carriers (D) and genetically modified cells (E). Non-viral delivery vehicles: cationic polymers (F.1), liposomes (F.2) and lipopolyplexes (F.3) [14].
Figure 3
Figure 3
In situ generation of NO from the micellar depots after phase transition in comparison to naked NO formed the NONOate donor [157].
See this image and copyright information in PMC

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