Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 25;57(9):872.
doi: 10.3390/medicina57090872.

The Urosepsis-A Literature Review

Mădălin Guliciuc  1   2 , Adrian Cornel Maier  2   3 , Ioana Maria Maier  3 , Alin Kraft  4 , Roxana Ramona Cucuruzac  5 , Monica Marinescu  3 , Cristina Şerban  1   2 , Laura Rebegea  1   2 , Georgiana Bianca Constantin  2 , Dorel Firescu  1   2
Affiliations
Review

The Urosepsis-A Literature Review

Mădălin Guliciuc et al. Medicina (Kaunas). .

Abstract

Urosepsis is a very serious condition with a high mortality rate. The immune response is in the center of pathophysiology. The therapeutic management of these patients includes surgical treatment of the source of infection, antibiotic therapy and life support. The management of this pathology is multidisciplinary and requires good collaboration between the urology, intensive care, imaging and laboratory medicine departments. An imbalance of pro and anti-inflammatory cytokines produced during sepsis plays an important role in pathogenesis. The study of cytokines in sepsis has important implications for understanding pathophysiology and for development of other therapeutic solutions. If not treated adequately, urosepsis may lead to serious septic complications and organ sequelae, even to a lethal outcome.

Keywords: review; urosepsis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., Peterson E., Tomlanovich M. Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. N. Engl. J. Med. 2001;345:1368–1377. doi: 10.1056/NEJMoa010307. - DOI - PubMed
    1. Reinhart K., Brunkhorst F.M., Bone H.-G., Bardutzky J., Dempfle C.-E., Forst H., Gastmeier P., Gerlach H., Gründling M., John S., et al. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI)) Ger. Med. Sci. 2010;8 doi: 10.3205/000103. - DOI - PMC - PubMed
    1. Levy M.M., Artigas A., Phillips G.S., Rhodes A., Beale R., Osborn T., Vincent J.-L., Townsend S., Lemeshow S., Dellinger R.P. Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: A prospective cohort study. Lancet Infect. Dis. 2012;12:919–924. doi: 10.1016/S1473-3099(12)70239-6. - DOI - PubMed
    1. Brun-Buisson C. The epidemiology of the systemic inflammatory response. Intensiv. Care Med. 2000;26:S064–S074. doi: 10.1007/s001340051121. - DOI - PMC - PubMed
    1. Hotchkiss R.S., Karl I.E. The Pathophysiology and Treatment of Sepsis. N. Engl. J. Med. 2003;348:138–150. doi: 10.1056/NEJMra021333. - DOI - PubMed