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. 2021 Sep 7;10(9):1151.
doi: 10.3390/pathogens10091151.

Investigation of Bufavirus and Parvovirus 4 in Patients with Gastro-Enteritis from the South-East of France

Francis Simo-Fouda  1 , Laurence Thirion  1 , Antoine Nougairède  1 , Léa Luciani  1 , Jean-Sélim Driouich  1 , Paul Rémi Petit  1 , Pascal Delaunay  2 , Remi N Charrel  1
Affiliations

Investigation of Bufavirus and Parvovirus 4 in Patients with Gastro-Enteritis from the South-East of France

Francis Simo-Fouda et al. Pathogens. .

Abstract

Bufavirus (BuV) and human parvovirus 4 (PARV4) belong to the Parvoviridae family. We assessed BuV and PARV4 DNA presence by real-time PCR analysis in stool, blood and respiratory samples collected in patients from Marseille and Nice, two large cities in the South-East of France. Bu-V DNA was detected in diarrheic stool samples from 92 patients (3.6% of 2583 patients), particularly men and adults, and patients from the nephrology and the infectious disease departments. Among the patients with a BuV-positive stool sample and for whom at least one blood sample was available (n = 30 patients), BuV DNA was detected also in 3 blood samples. In contrast, BuV DNA was not detected in any of the respiratory samples from 23 patients with BuV-positive stool. BuV detection rate was comparable in stool samples from patients with and without diarrhea. We did not detect PARV4 DNA in any of the stool specimens (n = 2583 patients). Our results suggest that PARV4 fecal-oral transmission is rare or non-existent in the South-East of France while BuV circulates with a relatively high rate in this area.

Keywords: France; Parvoviridae; Protoparvovirus; bufavirus; diarrhea; gastroenteritis; human parvovirus 4; parvovirus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
BuV viral load in the 107 BuV-positive stool samples.
Figure 2
Figure 2
Mortality rate by age group and BuV DNA status in Marseille (3 months after stool sample collection). The number above each column indicates the number of deceased patients.
See this image and copyright information in PMC

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