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Review
. 2021 Sep 20;13(9):1876.
doi: 10.3390/v13091876.

Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

Zijing Guo  1   2 , Zhidong Zhang  2 , Meera Prajapati  2   3 , Yanmin Li  2
Affiliations
Review

Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

Zijing Guo et al. Viruses. .

Abstract

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed.

Keywords: apoptosis; cytokines; immune response; lymphopenia; viruses.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
The underlying mechanisms of lymphopenia caused by viral infections.
See this image and copyright information in PMC

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