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Randomized Controlled Trial
. 2021 Sep 9;13(9):3144.
doi: 10.3390/nu13093144.

The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes

Ayoub Saeidi  1 , Mohammad Soltani  2 , Ali Daraei  3 , Hanieh Nohbaradar  4 , Marjan Mosalman Haghighi  5 , Nikoo Khosravi  4 , Kelly E Johnson  6 , Ismail Laher  7 , Anthony C Hackney  8 , Trisha A VanDusseldorp  9 , Hassane Zouhal  10
Affiliations
Randomized Controlled Trial

The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes

Ayoub Saeidi et al. Nutrients. .

Abstract

Background: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D).

Methods: Forty-four males with T2D were randomly allocated to four groups (n = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 weeks.

Results: Plasma dectin-1 levels were decreased in TS and TP groups compared with the CP group (p < 0.05). Cardiometabolic risk factors showed significant reductions in TP and TS groups compared to S and CP groups (p < 0.05).

Conclusion: The combination of CARET and broccoli supplementation produced the largest improvements in insulin resistance and dectin-1 and other complications of T2D.

Keywords: HOMA-IR; aerobic-strength training; body mass index; broccoli; concurrent exercise training; fat percent; inflammation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Participants flow chart. CP, Control–Placebo; S, Supplement; TP, Training–Placebo; TS, Training–Supplement.
Figure 2
Figure 2
Experimental design. CP, Control–Placebo; S, Supplement; TP, Training–Placebo; TS, Training–Supplement.
Figure 3
Figure 3
Pre and post training values (mean ± SD) for 3 Dectin-1. CP, Control–Placebo; S, Supplement; TP, Training–Placebo; TS, Training–Supplement groups. * indicates significant differences compared to the control group (p < 0.05). ‡ indicated significant difference from baseline (p < 0.05).
Figure 4
Figure 4
Pre and post training values (mean ± SD) for insulin in CP, Control–Placebo; S, Supplement; TP, Training–Placebo; TS, Training–Supplement groups. * indicates significant differences with control group (p < 0.05). * indicates significant differences compared to the control group (p < 0.05). # indicated significant differences compared to S group (p < 0.05). ‡ indicated significant difference from baseline (p < 0.05).
Figure 5
Figure 5
Pre and post training values (mean ± SD) for HOMA-IR in CP, Control–Placebo; S: Supplement; TP, Training–Placebo; TS, Training–Supplement groups. * indicates significant differences with control group (p < 0.05). * indicates significant differences compared to the control group (p < 0.05). # indicated significant differences compared to S group (p < 0.05). ‡ indicated significant difference from baseline (p < 0.05).
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