The complement cascade repurposed in the brain

Beth Stevens^{1

2

3}, Matthew B Johnson^{4

5

6}

Affiliations

¹ F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.
² Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Beth.Stevens@childrens.harvard.edu.
³ Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.
⁴ F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA, USA.
⁵ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁶ Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.

Beth Stevens et al. Nat Rev Immunol. 2021 Oct.

. 2021 Oct;21(10):624-625.

doi: 10.1038/s41577-021-00621-z.

Beth Stevens^{1

2

3}, Matthew B Johnson^{4

5

6}

¹ F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.
² Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Beth.Stevens@childrens.harvard.edu.
³ Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.
⁴ F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA, USA.
⁵ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁶ Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.

No abstract available

References

1. Stevens, B. et al. The classical complement cascade mediates CNS synapse elimination. Cell 131, 1164–1178 (2007) - DOI
1. Schafer, D. P. et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, 691–705 (2012) - DOI
1. Lehrman, E. K. et al. CD47 protects synapses from excess microglia-mediated pruning during development. Neuron 100, 120–134 (2018) - DOI
1. Hong, S. et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science 352, 712–716 (2016) - DOI
1. Sekar, A. et al. Schizophrenia risk from complex variation of complement component 4. Nature 530, 177–183 (2016) - DOI