Isthmin 1 - a novel insulin-like adipokine

Affiliations

¹ Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. l.scheja@uke.de.

Comment

Joerg Heeren et al. Nat Rev Endocrinol. 2021 Dec.

. 2021 Dec;17(12):709-710.

doi: 10.1038/s41574-021-00569-z.

¹ Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. l.scheja@uke.de.

No abstract available

Comment on

Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, Wabitsch M, Appel EA, Maikawa CL, Camporez JP, Shulman GI, Tsai L, Rosen ED, Gardner CD, Spiegelman BM, Svensson KJ. Jiang Z, et al. Cell Metab. 2021 Sep 7;33(9):1836-1852.e11. doi: 10.1016/j.cmet.2021.07.010. Epub 2021 Aug 3. Cell Metab. 2021. PMID: 34348115 Free PMC article.

1. Scheja, L. & Heeren, J. The endocrine function of adipose tissues in health and cardiometabolic disease. Nat. Rev. Endocrinol. 15, 507–524 (2019). - DOI
1. Osório, L., Wu, X. & Zhou, Z. Distinct spatiotemporal expression of ISM1 during mouse and chick development. Cell Cycle 13, 1571–1582 (2014). - DOI
1. Valle-Rios, R. et al. Isthmin 1 is a secreted protein expressed in skin, mucosal tissues, and NK, NKT, and th17 cells. J. Interferon Cytokine Res. 34, 795–801 (2014). - DOI
1. Jiang, Z. et al. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metab. 33, 1836–1852 (2021). - DOI
1. Heeren, J. & Scheja, L. Metabolic-associated fatty liver disease and lipoprotein metabolism. Mol. Metab. 50, 101238 (2021). - DOI