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. 2021 Sep 27;18(3):236-244.
doi: 10.4274/tjod.galenos.2021.74829.

Meta-analysis of the frequency of intrauterine growth restriction and preterm premature rupture of the membranes in pregnant women with COVID-19

Reza Bahrami  1 , David A Schwartz  2 , Mojgan Karimi-Zarchi  3 , Atiyeh Javaheri  4 , Seyed Alireza Dastgheib  5 , Farzad Ferdosian  6 , Mahmood Noorishadkam  7 , Seyed Reza Mirjalili  7 , Hossein Neamatzadeh  8
Affiliations

Meta-analysis of the frequency of intrauterine growth restriction and preterm premature rupture of the membranes in pregnant women with COVID-19

Reza Bahrami et al. Turk J Obstet Gynecol. .

Abstract

The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in pregnancy has yet to be determined. Some studies indicate that SARSCoV- 2 infection may be associated with a higher risk of adverse outcomes in pregnant women. Here, we performed a meta-analysis to estimate the frequency of intrauterine growth restriction (IUGR) and preterm premature rupture of the membranes (PPROM) in pregnant women with Coronavirus disease-2019 (COVID-19). A comprehensive search was performed in various databases, such as PubMed, Scopus, SciELO, MedRxiv, and Web of Science, to find all relevant studies published before 10 February 2021. Cross-sectional and consecutive case series reporting the pregnancy outcomes of COVID-19 were included. A total of 24 studies, including 8 studies on IUGR and 16 studies on PPROM, were selected. Pooled data showed that the frequencies of IUGR and PPROM in pregnant women with COVID-19 were 2.6% and 9.9%, respectively. Analyses stratified by ethnicity showed that the frequencies of IUGR in Asian and Caucasian COVID-19-infected pregnant women were 2.9% and 2.0%, respectively. Moreover, the frequencies of PPROM in Asian and Caucasian COVID-19-infected pregnant women were 10.2% and 5.8%, respectively. This meta-analysis showed that the frequencies of IUGR and PPROM in COVID-19-infected pregnant women were 2.6% and 9.9%, respectively. However, well-designed, large-scale and multicenter clinical studies are required to improve and validate these results.

Keywords: COVID-19; SARS-CoV-2; intrauterine growth restriction; pregnancy; preterm premature rupture of membranes.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
Study selection and inclusion process IUGR: Intrauterine growth restriction, PPROM: Preterm premature ruptures of membranes, COVID-19: Coronavirus disease-2019
Figure 2
Figure 2
Forest plots of the frequency of IUGR in pregnant women infected with SARS-CoV-2 in the (A) overall and (B) Caucasian populations IUGR: Intrauterine growth restriction, CI: Confidence interval, SARS-CoV-2: Severe acute respiratory syndrome coronavirus-2
Figure 3
Figure 3
Forest plots of the frequencies of PPROM in pregnant women with SARS-CoV-2 infection in the (A) overall, (B) Asian, and (C) Caucasian populations PPROM: Preterm premature rupture of the membranes, SARS-CoV-2: Severe acute respiratory syndrome coronavirus-2, CI: Confidence interval
Figure 4
Figure 4
Begg’s funnel plot to test for publication bias test on the frequencies of (A) IUGR and (B) PPROM in pregnant women with SARS-CoV-2 PPROM: Preterm premature rupture of the membranes, SARS-CoV-2: Severe acute respiratory syndrome coronavirus-2, IUGR: Intrauterine growth restriction
See this image and copyright information in PMC

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