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. 2021:1345:47-59.
doi: 10.1007/978-3-030-82735-9_5.

Cardiac Extracellular Matrix as a Platform for Heart Organ Bioengineering: Design and Development of Tissue-Engineered Heart

Aram Akbarzadeh  1 , Shabnam Sabetkish  1 , Abdol-Mohammad Kajbafzadeh  2
Affiliations

Cardiac Extracellular Matrix as a Platform for Heart Organ Bioengineering: Design and Development of Tissue-Engineered Heart

Aram Akbarzadeh et al. Adv Exp Med Biol. 2021.

Abstract

The field of tissue engineering and regenerative medicine is able to depict the mechanism of cardiac repair and development of cardiac function as well, in order to reveal findings to new therapeutic designs for clinical treatment. The foremost approach of this scientific field is the fabrication of scaffolds, which contain cells that can be used as cardiac grafts in the body, to have the preferred recovery. Cardiac tissue engineering has not been completely organized for routine clinical usages. Hence, engineering innovations hold promise to character research and treatment options in the years to come. Our group has extensive experience with regard to the structure of the heart, which makes us to our decision to continue with the preparation of heart, with the aim of developing a new ECM scaffold. Herein, we aim to assess the state-of-the-art fabrication methods, advances in decellularization and recellularization techniques. We also highlight the major achievements toward the production of a bioengineered heart obtained from decellularization and recellularization techniques.

Keywords: Cardiac stem cells; Decellularization; Heart matrices; Recellularization; Scaffold.

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References

    1. Akbarzadeh A, Khorramirouz R, Ghorbani F, Beigi RSH, Hashemi J, Kajbafzadeh AM (2019) Preparation and characterization of human size whole heart for organ engineering: scaffold microangiographic imaging. Regen Med 14(10):939–954. https://doi.org/10.2217/rme-2018-0111 - DOI - PubMed
    1. Akhyari P, Aubin H, Gwanmesia P, Barth M, Hoffmann S, Huelsmann J et al (2011) The quest for an optimized protocol for whole-heart decellularization: a comparison of three popular and a novel decellularization technique and their diverse effects on crucial extracellular matrix qualities. Tissue Eng Part C Methods 17(9):915–926. https://doi.org/10.1089/ten.TEC.2011.0210 - DOI - PubMed
    1. Alagarsamy KN, Yan W, Srivastava A, Desiderio V, Dhingra S (2019) Application of injectable hydrogels for cardiac stem cell therapy and tissue engineering. Rev Cardiovasc Med 20(4):221–230. https://doi.org/10.31083/j.rcm.2019.04.534 - DOI - PubMed
    1. Allegue C, Gil R, Blanco-Verea A, Santori M, Rodríguez-Calvo M, Concheiro L et al (2011) Prevalence of HCM and long QT syndrome mutations in young sudden cardiac death-related cases. Int J Legal Med 125(4):565–572. https://doi.org/10.1007/s00414-011-0572-7 - DOI - PubMed
    1. Aquila I, Marino F, Cianflone E, Marotta P, Torella M, Mollace V et al (2018) The use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin. Pharmacol Res 127:116–128. https://doi.org/10.1016/j.phrs.2017.06.012 - DOI - PubMed

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