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. 2021:1345:71-84.
doi: 10.1007/978-3-030-82735-9_7.

Decellularization of Small Intestinal Submucosa

Sahar Jelodari  1 , Esmaeil Sadroddiny  2
Affiliations

Decellularization of Small Intestinal Submucosa

Sahar Jelodari et al. Adv Exp Med Biol. 2021.

Abstract

Small intestinal submucosa (SIS) is the most studied extracellular matrix (ECM) for repair and regeneration of different organs and tissues. Promising results of SIS-ECM as a vascular graft, led scientists to examine its applicability for repairing other tissues. Overall results indicated that SIS grafts induce tissue regeneration and remodeling to almost native condition. Investigating immunomodulatory effects of SIS is another interesting field of research. SIS can be utilized in different forms for multiple clinical and experimental studies. The aim of this chapter is to investigate the decellularization process of SIS and its common clinical application.

Keywords: Decellularization; ECM; Scaffold; Small intestine; Submucosa.

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References

    1. Aachoui Y, Ghosh SK (2011) Extracellular matrix from porcine small intestinal submucosa (SIS) as immune adjuvants. PLoS One 6(11):e27083. https://doi.org/10.1371/journal.pone.0027083
    1. Abraham GA, Murray J, Billiar K, Sullivan SJ (2000) Evaluation of the porcine intestinal collagen layer as a biomaterial. J Biomed Mater Res 51(3):442–452 - DOI
    1. Aiken SW, Badylak SF, Toombs JP, Shelbourne KD, Hiles MC, Lantz GC, Van Sickle D (1994) Small intestinal submucosa as an intra-articular ligamentous graft material: a pilot study in dogs. Vet Comp Orthop Traumatol 07(03):124–128. https://doi.org/10.1055/s-0038-1633133 - DOI
    1. Andree B, Bar A, Haverich A, Hilfiker A (2013) Small intestinal submucosa segments as matrix for tissue engineering: review. Tissue Eng Part B Rev 19(4):279–291. https://doi.org/10.1089/ten.TEB.2012.0583 - DOI - PubMed
    1. Androjna C, Spragg RK, Derwin KA (2007) Mechanical conditioning of cell-seeded small intestine submucosa: a potential tissue-engineering strategy for tendon repair. Tissue Eng 13(2):233–243. https://doi.org/10.1089/ten.2006.0050 - DOI - PubMed - PMC

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