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. 2021:1345:225-239.
doi: 10.1007/978-3-030-82735-9_18.

Decellularization of Bone Tissue

Ha Le Bao Tran  1 , Vu Nguyen Doan  2 , Quan Minh To  2 , My Thi Ngoc Nguyen  2 , Van Ngoc Le Trinh  2 , Tuyet Thi Vi Le  2
Affiliations

Decellularization of Bone Tissue

Ha Le Bao Tran et al. Adv Exp Med Biol. 2021.

Abstract

Decellularization technology is a process that uses different methods such as physical, chemical or enzymatic methods in order to eliminate cellular remnants from original tissues or organs while minimizing any adverse effect on the structural properties, biological activity, and mechanical integrity of the remaining ECM. Regenerative medicine uses the most promising therapies to replace or regenerate tissues and organs in human, restore or establish normal functions lost due to disease or injury. By the combination between new biomaterials and cells, one of the goals of regenerative medicine is to create autologous grafts for transplantation therapies in the future.Various decellularization methods have been developed include chemical treatment, biological treatment and physical treatment. The aim of this chapter is to evaluate the decellularization method and all available materials that preserves the matrix without structural disruption.

Keywords: Bone; Decellularization; Extracellular matrix; Scaffolds.

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References

    1. Alford AI, Kozloff KM, Hankenson KD (2015) Extracellular matrix networks in bone remodeling. Int J Biochem Cell Biol 65:20–31 - PubMed - DOI
    1. Badylak SF (2004) Xenogeneic extracellular matrix as a scaffold for tissue reconstruction. Transpl Immunol 12(3–4):367–377 - PubMed - DOI - PMC
    1. Baker BM, Mauck RL (2007) The effect of nanofiber alignment on the maturation of engineered meniscus constructs. Biomaterials 28(11):1967–1977 - PubMed - PMC - DOI
    1. Bansal M, Bhagat S, Shukla D (2009) Bovine cancellous xenograft in the treatment of tibial plateau fractures in elderly patients. Int Orthop 33(3):779–784 - PubMed - DOI
    1. Barakat O, Abbasi S, Rodriguez G, Rios J, Wood RP, Ozaki C, Holley LS, Gauthier PK (2012) Use of decellularized porcine liver for engineering humanized liver organ. J Surg Res 173(1):e11–e25 - PubMed - DOI

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