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. 1986 Apr;83(8):2684-8.
doi: 10.1073/pnas.83.8.2684.

Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients

R R Weichselbaum, W Dahlberg, M Beckett, T Karrison, D Miller, J Clark, T J Ervin

Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients

R R Weichselbaum et al. Proc Natl Acad Sci U S A. 1986 Apr.

Abstract

Inherent cellular radioresistance and repair of x-ray damage was studied in 19 early-passage squamous cell carcinoma lines derived from head- and neck-cancer patients with known clinical results following radiotherapy. Human tumor cells that were radioresistant and/or proficient in accumulation/repair of x-ray damage were cultured from patients unsuccessfully treated with radiotherapy. Thus, the presence of radiation-resistant and repair-proficient tumor cells was associated with clinical radiation failure, suggesting the possibility of a predictive assay based on in vitro radiobiological parameters.

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References

    1. Cancer. 1985 May 1;55(9 Suppl):2118-22 - PubMed
    1. Cancer Res. 1981 May;41(5):1657-63 - PubMed
    1. Nature. 1959 Oct 24;184:1293-5 - PubMed
    1. Cancer Treat Rep. 1984 Jan;68(1):117-25 - PubMed
    1. Cancer Res. 1978 Feb;38(2):390-2 - PubMed

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