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. 2021 Sep 1;22(9):2867-2871.
doi: 10.31557/APJCP.2021.22.9.2867.

Association of IL-6 -174G>C and -572G>C Polymorphisms with Susceptibility to Cervical Cancer and Ovarian Cancer

Ahmad Hashemzehi  1 , Mojgan Karimi-Zarchi  2   3 , Seyedeh Fatemeh Parsaeian  4 , Fatemeh Asadian  5 , Hossein Golestanpour  6   7 , Sepideh Setayesh  8 , Seyed Amir Shaker  9 , Masoud Zare-Shehneh  10 , Hossein Neamatzadeh  10   11
Affiliations

Association of IL-6 -174G>C and -572G>C Polymorphisms with Susceptibility to Cervical Cancer and Ovarian Cancer

Ahmad Hashemzehi et al. Asian Pac J Cancer Prev. .

Abstract

Background: During the past decades, the expansion of molecular development has had a key role in understanding the basis of gynecological cancer. Interleukin-6 (IL-6) is known to be involved in the pathogenesis of different cancers. Here, we evaluated the association of IL-6 -174G>C and -572 G>C polymorphisms with susceptibility to cervical and ovarian cancers in an Iranian population.

Methods: A total of 131 cases with ovarian cancer, 124 cases with cervical cancer and 140 healthy subjects were enrolled to the study. DNA was extracted from peripheral blood cells of subjects to genotype the IL-6 -174G>C and -572 G>C polymorphisms by amplification refractory mutation system (RFLP) polymerase chain reaction (PCR).

Results: There was a significant association of IL-6 -174G>C CC genotype (OR= 3.231, 95% CI: 1.130-9.239, p=0.029) and C allele (OR = 1.915; 95%CI: 1.266-2.896, p=0.002) with an increased risk of ovarian cancer. Moreover, the IL-6 -174G>C CC genotype (OR= 3.162, 95% CI: 1.094-9.141, p=0.034) and C allele (OR = 1.724; 95%CI: 1.129-2.633, p=0.012) was associated with increased risk of cervical cancer.

Conclusions: This study showed that the IL-6 -174G>C polymorphism was associated with ovarian cancer and cervical cancer risk. However, IL-6 -572 G>C polymorphism was not associated.

Keywords: Cervical cancer; Interleukin 6; Ovarian Cancer; Polymorphism.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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