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Comment
. 2021 Sep 27;56(18):2545-2546.
doi: 10.1016/j.devcel.2021.09.003.

Is developmental synchrony enabled by CTCF residence time?

Hsiao-Lin V Wang  1 , Victor G Corces  2
Affiliations
Comment

Is developmental synchrony enabled by CTCF residence time?

Hsiao-Lin V Wang et al. Dev Cell. .

Abstract

Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.

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Conflict of interest statement

Declaration of Interests

The authors declare no competing interests

Figures

Figure 1.
Figure 1.. Regulation of chromatin residence time by ZF8.
(A) Structure of CTCF drawn using WebGL and coordinates deposited under accession 5YEL. Only ZF6-ZF11 bound to DNA are shown. ZF8 serves as a linker between ZF7, which recognizes specific bases in the major groove, and ZF9, which interacts with module D at a subset of sites in the genome and with the phosphate backbone at the rest. (B) Illustration of changes in CTCF chromatin residence time when ZF8 is deleted.
See this image and copyright information in PMC

Comment on

References

    1. Arzate-Mejía RG, Recillas-Targa F, and Corces VG (2018). Developing in 3D: the role of CTCF in cell differentiation. Development 145, dev137729. 10.1242/dev.137729. - DOI - PMC - PubMed
    1. Hansen AS, Pustova I, Cattoglio C, Tjian R, and Darzacq X (2017). CTCF and cohesin regulate chromatin loop stability with distinct dynamics. Elife 6. 10.7554/eLife.25776. - DOI - PMC - PubMed
    1. Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, and Cheng X (2017). Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Molecular Cell 66, 711 720.e713. 10.1016/j.molcel.2017.05.004. - DOI - PMC - PubMed
    1. Konrad EDH, Nardini N, Caliebe A, Nagel I, Young D, Horvath G, Santoro SL, Shuss C, Ziegler A, Bonneau D, et al. (2019). CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum. Genet Med 21, 2723–2733. 10.1038/s41436-019-0585-z. - DOI - PMC - PubMed
    1. Nakahashi H, Kieffer Kwon KR, Resch W, Vian L, Dose M, Stavreva D, Hakim O, Pruett N, Nelson S, Yamane A, et al. (2013). A genome-wide map of CTCF multivalency redefines the CTCF code. Cell Rep 3, 1678–1689. 10.1016/j.celrep.2013.04.024. - DOI - PMC - PubMed

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