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Comment
. 2021 Sep 28;9(3):E886-E896.
doi: 10.9778/cmajo.20200164. Print 2021 Jul-Sep.

Hepatitis C virus infection in First Nations populations in Ontario from 2006 to 2014: a population-based retrospective cohort analysis

Andrew Mendlowitz  1 , Karen E Bremner  2 , Jennifer D Walker  2 , William W L Wong  2 , Jordan J Feld  2 , Beate Sander  2 , Lyndia Jones  2 , Wanrudee Isaranuwatchai  2 , Murray Krahn  2
Affiliations
Comment

Hepatitis C virus infection in First Nations populations in Ontario from 2006 to 2014: a population-based retrospective cohort analysis

Andrew Mendlowitz et al. CMAJ Open. .

Abstract

Background: Hepatitis C virus (HCV) infection causes substantial morbidity and mortality in Canada and is of concern among First Nations communities. In partnership with the Ontario First Nations HIV/AIDS Education Circle, we described trends in HCV testing and epidemiologic features among Status First Nations people in Ontario.

Methods: In this retrospective study, we used health administrative databases for 2006-2014 in Ontario with 3 cohorts of Status First Nations people: those tested for HCV for the first time, those who tested positive for HCV antibodies or RNA, and those with no HCV laboratory or testing records. We examined cohort characteristics, and the annual prevalence and incidence of testing and diagnosis of HCV infection. Outcomes were stratified by region, sex and residence within or outside of First Nations communities.

Results: During the study period, 2423 Status First Nations people were diagnosed with HCV infection, 20 481 received their first test, and 135 185 had no test record. The point prevalence of ever having been tested increased from 6.3 (95% confidence interval [CI] 6.2-6.5) per 100 people in 2006 to 16.2 (95% CI 16.0-16.4) per 100 people in 2014. The point prevalence of diagnosed HCV infection increased from 0.9 (95% CI 0.9-1.0) to 2.0 (95% CI 1.9-2.0) per 100 people. The incidence of first test and of diagnosis increased from 12.1 (95% CI 11.5-12.6) to 21.3 (95% CI 20.5-22.1) per 1000 person-years and from 1.3 (95% CI 1.1-1.5) to 2.3 (95% CI 2.1-2.6) per 1000 person-years, respectively. Testing, diagnosis and prevalence of HCV infection were consistently higher among people living outside of versus within First Nations communities, but larger increases over time were observed among those living within First Nations communities.

Interpretation: Testing and diagnosis of HCV infection increased from 2006 to 2014 among Status First Nations people in Ontario. Our findings indicate the need for population-level efforts to eliminate hepatitis C in First Nations communities.

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Conflict of interest statement

Competing interests: William Wong and Murray Krahn report research support from the Canadian Liver Foundation, outside the submitted work. Jordan Feld reports institutional research support from AbbVie, Enanta Pharmaceuticals, Gilead Sciences and Janssen, and consulting fees from AbbVie and Gilead Sciences. No other competing interests were declared.

Figures

Figure 1:
Figure 1:
Flow diagram showing cohort selection. Testing records for the same person on the same day were combined to be a record of a single sample collection. *People who had a testing or diagnosis date in the year of their death still contributed to their respective annual case count for that respective year. †Up to 5 people were excluded because their testing or diagnosis date was more than a year after their death. Note: HCV = hepatitis C virus.
Figure 2:
Figure 2:
(A) Annual age- and sex-standardized incidence per 1000 person-years of first test for hepatitis C virus (HCV) infection among Status First Nations people. (B) Annual age- and sex-standardized point prevalence per 100 people of ever having been tested for HCV infection among Status First Nations people measured at Dec. 31 each year. Error bars represent 95% confidence intervals.
Figure 3:
Figure 3:
(A) Annual age- and sex-standardized incidence per 1000 person-years of diagnosed hepatitis C virus (HCV) infection among Status First Nations people. (B) Annual age- and sex-standardized point prevalence per 100 people of diagnosed HCV infection among Status First Nations people measured at Dec. 31 each year. Error bars represent 95% confidence intervals.
Figure 4:
Figure 4:
Age- and sex-standardized point prevalence per 100 people of ever having been tested for hepatitis C virus (HCV) infection among Status First Nations people at Dec. 31, 2014, by Local Health Integration Network (LHIN).
Figure 5:
Figure 5:
Age- and sex-standardized point prevalence per 100 people of diagnosed hepatitis C virus (HCV) infection among Status First Nations people at Dec. 31, 2014, by Local Health Integration Network (LHIN).
Figure 6:
Figure 6:
Age- and sex-standardized incidence per 1000 person-years of first hepatitis C virus (HCV) test among Status First Nations people from 2006 to 2014, by Local Health Integration Network (LHIN).
Figure 7:
Figure 7:
Age- and sex-standardized incidence per 1000 person-years of diagnosed hepatitis C virus (HCV) infection among Status First Nations people from 2006 to 2014, by Local Health Integration Network (LHIN).
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Comment on

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