Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct 1;61(4):109-124.
doi: 10.1097/IIO.0000000000000378.

Retinal Gene Therapy for Usher Syndrome: Current Developments, Challenges, and Perspectives

Astra Dinculescu, Brian A Link, David A Saperstein

Retinal Gene Therapy for Usher Syndrome: Current Developments, Challenges, and Perspectives

Astra Dinculescu et al. Int Ophthalmol Clin. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Detection of CLRN1 transcripts in piglet retina at postnatal day P2 using the RNAscope ISH assay (red punctate staining). GCL indicates ganglion cell layer; INL, inner nuclear layer; ISH, in situ hybridization; ONL, outer nuclear layer; RPE, retinal pigment epithelium. The paraffin-embedded retina tissue sections were counterstained with Gill hematoxylin to visualize nuclei (blue). Scale bar: 20 µm.
See this image and copyright information in PMC

References

    1. Toms M, Pagarkar W, Moosajee M. Usher syndrome: clinical features, molecular genetics and advancing therapeutics. Ther Adv Ophthalmol. 2020;12:2515841420952194. - PMC - PubMed
    1. Mathur P, Yang J. Usher syndrome: hearing loss, retinal degeneration and associated abnormalities. Biochim Biophys Acta. 2015;1852:406–420. - PMC - PubMed
    1. Petit C. Usher syndrome: from genetics to pathogenesis. Annu Rev Genomics Hum Genet. 2001;2:271–297. - PubMed
    1. Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006;368:1795–1809. - PubMed
    1. Usher CH. On the inheritance of retinitis pigmentosa; with notes of cases. Roy Lond Ophthalmol Hosp Rep. 1914;19:130–236.

Publication types

LinkOut - more resources