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Review
. 2021 Sep 15:2021:3149223.
doi: 10.1155/2021/3149223. eCollection 2021.

Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases

Cristina Quispe  1 , Natália Cruz-Martins  2   3   4 , Maria Letizia Manca  5 , Maria Manconi  5 , Oksana Sytar  6   7 , Nataliia Hudz  8 , Mariia Shanaida  9 , Manoj Kumar  10 , Yasaman Taheri  11 , Miquel Martorell  12   13 , Javad Sharifi-Rad  11 , Gianfranco Pintus  14   15 , William C Cho  16
Affiliations
Review

Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases

Cristina Quispe et al. Oxid Med Cell Longev. .

Abstract

Due to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology applications used to enhance CUR bioavailability and its targeted delivery in specific pathological conditions are collected and discussed. In particular, new aspects concerning the main strategic nanocarriers employed for treating inflammation and oxidative stress-related diseases are reported and discussed, with specific emphasis on those topically employed in conditions such as wounds, arthritis, or psoriasis and others used in pathologies such as bowel (colitis), neurodegenerative (Alzheimer's or dementia), cardiovascular (atherosclerosis), and lung (asthma and chronic obstructive pulmonary disease) diseases. A brief overview of the relevant clinical trials is also included. We believe the review can provide the readers with an overview of the nanostrategies currently employed to improve CUR therapeutic applications in the highlighted pathological conditions.

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Conflict of interest statement

The authors declare no conflict of interests.

Figures

Figure 1
Figure 1
Turmeric (a) as a source of CUR; tautomeric forms of CUR (b): keto-form (B1) and enol-form (B2).
Figure 2
Figure 2
Biological activities of curcumin.
Figure 3
Figure 3
Protective effect of curcumin-loaded nanocarriers on various ailments in human body.
See this image and copyright information in PMC

References

    1. Pulido-Moran M., Moreno-Fernandez J., Ramirez-Tortosa C., Ramirez-Tortosa M. Curcumin and health. Molecules. 2016;21(3):p. 264. doi: 10.3390/molecules21030264. - DOI - PMC - PubMed
    1. Kumar S., Ahuja V., Sankar M. J., Kumar A., Moss A. C. Curcumin for maintenance of remission in ulcerative colitis. Cochrane Database of Systematic Reviews. 2012;10 doi: 10.1002/14651858.CD008424.pub2. - DOI - PMC - PubMed
    1. Aggarwal B. B., Harikumar K. B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. The International Journal of Biochemistry & Cell Biology. 2009;41:40–59. doi: 10.1016/j.biocel.2008.06.010. - DOI - PMC - PubMed
    1. Ghasemian M., Owlia S., Owlia M. B. Review of anti-inflammatory herbal medicines. Advances in Pharmacological Sciences. 2016;2016 doi: 10.1155/2016/9130979.9130979 - DOI - PMC - PubMed
    1. Lee S.-Y., Cho S.-S., Li Y., Bae C.-S., Park K. M., Park D.-H. Anti-inflammatory effect of Curcuma longa and Allium hookeri co-treatment via NF-κB and COX-2 pathways. Scientific Reports. 2020;10:p. 5718. doi: 10.1038/s41598-020-62749-7. - DOI - PMC - PubMed